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吴月峰,陈定芳,朱志飞,刘有志,李海英,周燕子,王敏存,袁筱,周晋,贺福元.桑源中药用药规律及超分子作用机制研究[J].湖南中医药大学学报英文版,2021,41(11):1807-1812.[Click to copy
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| 桑源中药用药规律及超分子作用机制研究 |
| 吴月峰,陈定芳,朱志飞,刘有志,李海英,周燕子,王敏存,袁筱,周晋,贺福元 |
| (湖南中医药大学药学院, 湖南 长沙 410208;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医药超分子机理与数理特征化实验室, 湖南 长沙 410208) |
| 摘要: |
| 本文以超分子“印迹模板”自主作用规律为基础，旨在阐明桑源中药“同源异效”用药规律的超分子作用机制：由于中药和人体均为由超分子自识别、自组装、自组织、自复制而成的巨复超分子体。在体内气析作用下，“印迹模板”与外邪侵扰状态下的超分子体产生印迹作用，纠正机体的病理状态。桑源中药在机体内“印迹模板”差异的程度及变化的程度就是造成“异效”的物质基础。该理论能为桑源中药及其他“同源异效”中药的用药规律及“同病异治”机制研究提供借鉴。 |
| 关键词: 超分子化学 桑源中药 同源异效 印迹模板 用药规律 历史沿革 用药现状 |
| DOI：10.3969/j.issn.1674-070X.2021.11.028 |
| Received:April 09, 2021 |
| 基金项目:国家自然科学基金项目（81903759）；国家留学基金项目（201708430243）；长沙市科学技术局项目（kq2004059）；湖南中医药大学药学一流学科开放基金资助项目（2021YX16）；湖南省研究生科研创新项目（CX20210711）。 |
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| Study on Medication Rules and Supramolecular Mechanism of Mulberry Source Chinese Medicine |
| WU Yuefeng,CHEN Dingfang,ZHU Zhifei,LIU Youzhi,LI Haiying,ZHOU Yanzi,WANG Mincun,YUAN Xiao,ZHOU Jin,HE Fuyuan |
| (College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha, Hunan 410208, China;Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| To expound the supramolecular action mechanism of mulberry source Chinese medicine "homologous but different effect" based on the autonomous action rule of supramolecular "imprinted template". Traditional Chinese medicine and human body are giant supramolecular bodies formed by supramolecular self-recognition, self-assembly, self-organization and self-replication. Under the action of Qi segregation in vivo, "imprinted template" produces imprinting effect with supramolecular bodies under the condition of external evil invasion, and corrects the pathological state of the body. The degree of difference and change of "imprinted template" in mulberry source Chinese medicine in the body is the material basis for "different effect". This theory can provide reference for the study of the medication rule of mulberry source Chinese medicine and other "homologous but different effect" traditional Chinese medicine and the mechanism of "same disease and different treatment". |
| Key words: supramolecular chemistry mulberry source Chinese medicine homologous but different effect imprinted template medication rules historic evolution status of medication |
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