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刘盛扶,李小林,刘俊峰.桃红四物汤加味联合依帕司他对老年糖尿病周围神经病变的临床观察[J].湖南中医药大学学报英文版,2021,41(9):1431-1435.[Click to copy
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| 桃红四物汤加味联合依帕司他对老年糖尿病周围神经病变的临床观察 |
| 刘盛扶,李小林,刘俊峰 |
| (黄石市第二医院, 湖北 黄石 435002) |
| 摘要: |
| 目的 探讨桃红四物汤加味联合依帕司他治疗老年糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）的临床疗效，分析其对血脂和氧化应激指标的影响。方法 选择2018年3月至2020年5月于我院内分泌科就诊的103例老年DPN患者，随机分为两组。对照组（51例）采用依帕司他治疗，观察组（52例）采用桃红四物汤加味联合依帕司他治疗，疗程均为2个月。比较两组疗效、中医证候积分、多伦多临床评分系统（TCSS）、神经病变自觉症状问卷的症状总评分（TSS）、血脂和氧化应激指标差异。结果 观察组治疗有效率93.31%，高于对照组的76.47%（P<0.05）。观察组治疗后中医证候积分、TCSS评分、TSS评分、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、晚期氧化蛋白产物水平低于对照组（P<0.01），高密度脂蛋白胆固醇、谷胱甘肽过氧化物酶、总抗氧化能力、超氧化物歧化酶水平高于对照组（P<0.01）。结论 桃红四物汤加味联合依帕司他可改善老年糖尿病DPN患者血脂异常，降低氧化应激反应，提高临床疗效。 |
| 关键词: 桃红四物汤 依帕司他 糖尿病 周围神经病变 老年 血脂 氧化应激 |
| DOI：10.3969/j.issn.1674-070X.2021.09.021 |
| Received:December 17, 2020 |
| 基金项目:湖北省卫健委联合基金面上项目（W2019H475）。 |
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| The Clinical Effect of Taohong Siwu Decoction Combined with Epalrestat on Senile Diabetic Peripheral Neuropathy |
| LIU Shengfu,LI Xiaolin,LIU Junfeng |
| (The Second Hospital of Huangshi City, Huangshi, Hubei 435002, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Taohong Siwu Decoction combined with epalrestat in the treatment of senile diabetic peripheral neuropathy (DPN), and to analyze its effect on blood lipid and oxidative stress index. Methods A total of 103 elderly patients with DPN who visited the Department of Endocrinology of our hospital from March 2018 to May 2020 were selected and randomly divided into two groups. The control group (51 cases) was treated with epalrestat, the treatment group (52 cases) was treated with Taohong Siwu Decoction combined with epalrestat. The treatment course was 2 months. The therapeutic effect, syndrome score of traditional Chinese medicine (TCM), Toronto clinical scoring system (TCSS), total symptoms score (TSS) of the neuropathy conscious symptom questionnaire, blood lipid and oxidative stress index were compared between the two groups. Results The effective rate of the treatment group was 93.31%, higher than 76.47% of the control group (P<0.05). After treatment, the levels of TCM syndrome scores, TCSS scores, TSS scores, total cholesterol, triglyceride, low-density lipoprotein cholesterol and advanced oxidized protein products in the treatment group were lower than those in the control group (P<0.01). The levels of high-density lipoprotein cholesterol, glutathione peroxidase, total anti-oxidation capacity and superoxide dismutase were higher than those of the control group (P<0.01). Conclusion Taohong Siwu Decoction combined with epalrestat can improve dyslipidemia, reduce oxidative stress and improve clinical efficacy in elderly patients with DPN. |
| Key words: Taohong Siwu Decoction epalrestat diabetes peripheral neuropathy elderly blood lipid oxidative stress |
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