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张先恒,刘健,周琴,丁香,陈晓露.基于数据挖掘分析黄芩清热除痹胶囊对痛风合并高脂血症患者生化检测指标的影响[J].湖南中医药大学学报英文版,2021,41(9):1389-1394.[Click to copy
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| 基于数据挖掘分析黄芩清热除痹胶囊对痛风合并高脂血症患者生化检测指标的影响 |
| 张先恒,刘健,周琴,丁香,陈晓露 |
| (安徽中医药大学, 安徽 合肥 230031;安徽中医药大学第一附属医院, 安徽 合肥 230031) |
| 摘要: |
| 目的 运用数据挖掘方法探究黄芩清热除痹胶囊联合常规治疗对痛风合并高脂血症患者生化检测指标的影响。方法 调取并整理2012年6月至2020年10月在安徽中医药大学第一附属医院风湿病科确诊的796例痛风合并高脂血症患者的病历资料，依据黄芩清热除痹胶囊的使用情况，将患者分为观察组329例和对照组467例。比较两组治疗前后的生化检测指标变化；采用数据挖掘分析两组患者所用中药方剂的用药规律；采用随机行走模型评价两组患者的治疗情况。结果 （1）对照组中甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、超敏-C反应蛋白（hs-CRP）、血沉（ESR）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、补体C3（C3）、补体C4（C4）、尿酸（UA）治疗后指标值改善（P<0.05）；观察组中TG、hs-CRP、ESR、IgA、IgM、C3、C4、UA治疗后指标值改善（P<0.05）；两组治疗前后差值比较中，观察组TG、ESR、UA指标优于对照组（P<0.05）。（2）796例患者所用处方2 771首，涉及中药283味。药性主要集中于温、寒、平3性；药味以甘、苦、辛最为频繁；归经以肝、肺、脾、胃、肾为主；所涉中药以健脾化湿药为主。（3）关联分析结果显示：使用黄芩清热除痹胶囊后，UA的降低与郁金、土茯苓、薏苡仁、陈皮、黄柏关联度较高；TG的降低与山慈菇、黄柏、威灵仙、郁金、泽兰关联度较高；ESR的降低与山药、川牛膝、桃仁、威灵仙、蒲公英、黄柏关联度较高。（4）随机行走模型显示：两组患者TG、UA、ESR的改善与干预措施存在长程关联，且观察组优于对照组。结论 中医健脾疗法能有效改善痛风合并高脂血症患者血脂、炎症、尿酸指标，联合黄芩清热除痹胶囊后疗效更优。 |
| 关键词: 痛风 高脂血症 黄芩清热除痹胶囊 用药规律 随机行走模型 血脂 炎症 尿酸 |
| DOI：10.3969/j.issn.1674-070X.2021.09.013 |
| Received:May 19, 2021 |
| 基金项目:国家自然科学基金面上项目（81973655）；科技部国家重点研发计划中医药现代化研究重点专项（2018YFC1705204）；全国中医药创新骨干人才培训项目（国中医药人教函〔2019〕128号）；安徽省重点研究和开发计划对外科技合作项目（201904b11020011）。 |
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| Effects of Huangqin Qingrejiebi Capsule on Biochemical Indexes of Patients with Gout Complicated with Hyperlipidemia Based on Data Mining |
| ZHANG Xianheng,LIU Jian,ZHOU Qin,DING Xiang,CHEN Xiaolu |
| (Anhui University of Chinese Medicine, Hefei, Anhui 230031, China;The First Affliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China) |
| Abstract: |
| Objective To explore the effect of Huangqin Qingrechubi Capsule combined with routine treatment on biochemical indexes of patients with gout complicated with hyperlipidemia based on data mining method. Methods The medical records of 796 cases of gout combined with hyperlipidemia patient in Rheumatism Department of The First Affliated Hospital of Anhui University of Chinese Medicine in June 2012 to October 2020 were collected and collated, according to the usage of Huangqin Qingrechubi Capsule, patients were divided into 329 cases of observation group and 467 cases of control group. The changes of biochemical indexes before and after treatment were compared between the two groups; data mining was used to analyze the medication rules of traditional Chinese medicine prescriptions used by the two groups; the treatment status of the two groups was evaluated by random walking model. Results (1) The index values of triglyceride (TG), high density lipoprotein cholesterol (HDL-C), hypersensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), immunoglobulin A (IgA), immunoglobulin M (IgM), complement C3 (C3), complement C4 (C4) and uric acid (UA) in the control group were improved after treatment (P<0.05). The index values of TG, hs-CRP, ESR, IgA, IgM, C3, C4 and UA in the observation group were improved after treatment (P<0.05). TG, ESR and UA in the observation group were better than those in the control group (P<0.05). (2) 2 771 prescriptions were used in 796 patients, involving 283 kinds of traditional Chinese medicine. Drug properties mainly concentrated in warm, cold, flat; the most frequent medicinal tastes were sweet, bitter and pungent; the main channels were liver, lung, spleen, stomach and kidney; the traditional Chinese medicine involved mainly invigorates the spleen and reduces dampness. (3) Correlation analysis showed that the decrease of UA was highly correlated with Yujin (Curcumae Radix), Tufuling (Smilacis Glabrae Rhizoma), Yiyiren (Coicis Semen), Chenpi (Citri Reticulatae Pericarpium), Huangbo (Phellodendri Chinensis Cortex) after using Huangqin Qingrechubi Capsule; the decrease of TG was highly correlated with Shancigu (Cremastrae Pseudobulbus Pleiones Pseudobulbus), Huangbo (Phellodendri Chinensis Cortex), Weilingxian (Clematidis Radix Et Rhizoma), Yujin (Curcumae Radix), Zelan (Lycopi Herba); the decrease of ESR was correlated with Shanyao (Dioscoreae Rhizoma), Chuanniuxi (Cyathulae Radix), Taoren (Persicae Semen), Weilingxian (Clematidis Radix Et Rhizoma), Pugongying (Taraxaci Herba), Huangbo (Phellodendri Chinensis Cortex). (4) The random walking model showed that the improvement of TG, UA and ESR in the two groups was associated with the intervention in a long range, and the observation group was superior to the control group. Conclusion Traditional Chinese medicine spleen-strengthening therapy can effectively improve the indexes of blood lipid, inflammation and uric acid in patients with gout combined with hyperlipidemia and after combination of Huangqin Qingrechubi Capsule, the curative effect is better. |
| Key words: gout hyperlipidemia Huangqin Qingrechubi Capsule medication rule random walk model blood lipid inflammation uric acid |
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