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孟繁词,张天婵,于洋,韩莹,丛慧芳.活血化瘀类中药治疗子宫内膜异位症作用机制的研究进展[J].湖南中医药大学学报英文版,2021,41(8):1307-1312.[Click to copy
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| 活血化瘀类中药治疗子宫内膜异位症作用机制的研究进展 |
| 孟繁词,张天婵,于洋,韩莹,丛慧芳 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001) |
| 摘要: |
| 子宫内膜异位症是一种激素依赖性疾病，已成为妇科及生殖医学科的难题，长期困扰女性，严重影响了育龄期妇女的生活质量。中医学认为血瘀是本病的基本病机，在治疗上当着重选择活血化瘀类中药。综合2016年至2021年国内外相关文献资料，从下调炎症因子的相对表达、诱导异位内膜细胞凋亡、抑制血管生成、调节肠道菌群、免疫调节等方面阐明活血化瘀类中药治疗子宫内膜异位症的作用途径及靶点，使其作用机制得到更全面的揭示。 |
| 关键词: 子宫内膜异位症 血瘀 中药 活血化瘀 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2021.08.030 |
| Received:March 12, 2021 |
| 基金项目:国家自然科学基金青年科学基金项目（81704113）。 |
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| Research Progress on Mechanism of Endometriosis Treated by Traditional Chinese Medicine of Promoting Blood Circulation and Removing Blood Stasis |
| MENG Fanci,ZHANG Tianchan,YU Yang,HAN Ying,CONG Huifang |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China) |
| Abstract: |
| Endometriosis is a hormone dependent disease, which has become a difficult problem in gynecology and reproductive medicine. It has long plagued women and seriously affected the quality of life of women of childbearing age. Traditional Chinese medicine believes that blood stasis is the basic pathogenesis of the disease, and should focus on promoting blood circulation and removing blood stasis. Therefore, based on the relevant literature at home and abroad from 2016 to 2021, the author elucidates the pathway and target of traditional Chinese medicine for promoting blood circulation and removing blood stasis in the treatment of endometriosis:down regulating the relative expression of inflammatory factors, inducing apoptosis of ectopic endometrial cells, inhibiting angiogenesis, regulating intestinal flora, immune regulation and so on, so as to reveal its mechanism more comprehensively. |
| Key words: endometriosis blood stasis traditional Chinese medicine promoting blood circulation and removing blood stasis mechanism of action |
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