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许志,谢梦洲,许必祥,刘雪辉,贺静,王筱宇.鹜芪口服液联合化疗对Lewis肺癌小鼠增效减毒作用研究[J].湖南中医药大学学报英文版,2021,41(5):696-700.[Click to copy
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| 鹜芪口服液联合化疗对Lewis肺癌小鼠增效减毒作用研究 |
| 许志,谢梦洲,许必祥,刘雪辉,贺静,王筱宇 |
| (湖南天劲制药有限责任公司, 湖南 长沙 410205;湖南中医药大学, 湖南 长沙 41007) |
| 摘要: |
| 目的 观察鹜芪口服液联合化疗对Lewis肺癌小鼠化疗效果的影响。方法 将腋下接种Lewis肺癌细胞小鼠随机分为6组，分别为模型对照组、化疗组、化疗+贞芪扶正颗粒组（贞芪扶正组）、化疗+鹜芪口服液低剂量组（鹜芪低剂量组）、化疗+鹜芪口服液中剂量组（鹜芪中剂量组）、化疗+鹜芪口服液高剂量组（鹜芪高剂量组），同时设立正常对照组，各组按照给药方法进行连续给药21 d。给药后每隔3天，对Lewis肺癌小鼠的肿瘤的长径和短径进行测定、给药21 d后对血液中炎性细胞WBC、Neu、Lym、Mon、Eos、Bas的数目进行测定，并对胸腺、脾脏、胃进行组织病理学检查。结果 与化疗组比较，鹜芪低、中剂量组小鼠给药第15~21天肿瘤体积减少；鹜芪高剂量组小鼠给药第21天肿瘤体积明显减少（P<0.05）。与化疗组比较，鹜芪低、中、高剂量组小鼠血液中WBC、Neu、Mon、Eos数目明显减少（P<0.05或P<0.01）。鹜芪口服液联合化疗能明显改善小鼠脾脏红髓造血情况，改善胸腺萎缩和局灶性纤维化。结论 鹜芪口服液联合化疗用药对Lewis肺癌荷瘤小鼠具有明显的增效减毒作用。 |
| 关键词: 鹜芪口服液 化疗 肿瘤体积 增效减毒 炎性细胞 |
| DOI：10.3969/j.issn.1674-070X.2021.05.008 |
| Received:January 11, 2021 |
| 基金项目:湖南省教育厅创新平台基金项目（19K070）。 |
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| The Study About Effect-enhancing and Toxicity-reducing Effects of Wuqi Oral Liquid Combined with Chemotherapy in Mice with Lewis Lung Cancer |
| XU Zhi,XIE Mengzhou,XU Bixiang,LIU Xuehui,HE Jing,WANG Xiaoyu |
| (Hunan Tianjin Pharmaceutical Co., Ltd. Changsha, Hunan 410205, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the effect of Wuqi Oral Liquid combined with chemotherapy on the chemotherapy effect of Lewis lung cancer mice. Methods Mice inoculated with Lewis lung cancer cells under the armpits were randomly divided into 6 groups:model control group, chemotherapy group, chemotherapy+Zhenqi Fuzheng granule group (Zhenqi Fuzheng group), chemotherapy+Wuqi Oral Liquid low-dose group (Wuqi low-dose group), chemotherapy+Wuqi Oral Liquid medium-dose group (Wuqi medium-dose group), chemotherapy+Wuqi Oral Liquid high-dose group (Wuqi high-dose group), and a normal control group was set up at the same time, each group was dealt with the administration method. The administration of drug was continued for 21 days. The long and short diameters of the tumors in Lewis lung cancer mice were measured every 3 days after the administration. After 21 days of administration, the blood inflammatory cells WBC, Neu, Lym, Mon, Eos and Bas was measured, and histopathological examination was performed on the thymus, spleen, and stomach. Results Compared with the chemotherapy group, the volume of tumors in mice of Wuqi low and medium doses group decreased from 15 to 21 days after administration; the volume of tumors in mice of Wuqi high-dose group was significantly reduced on the 21st day (P<0.05). Compared with the chemotherapy group, the number of WBC, Neu, Mon, Eos inflammatory cells in the blood of mice of Wuqi low, medium and high doses group significantly reduced (P<0.05 or P<0.01). Wuqi Oral Liquid combined with chemotherapy can significantly improve the hematopoiesis of the red marrow of the mouse spleen, and improve thymic atrophy and focal fibrosis. Conclusion Wuqi Oral Liquid combined with chemotherapy has a significant effect of increasing efficacy and reducing toxicity in mice with Lewis lung cancer. |
| Key words: Wuqi Oral Liquid chemotherapy tumor volume effect-enhancing and toxicity-reducing inflammatory cells |
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