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岑怡,邢长英,梁芳,曲立娟.促排汤序贯治疗对多囊卵巢综合征患者行控制性超促排卵的影响[J].湖南中医药大学学报英文版,2021,41(3):462-466.[Click to copy
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| 促排汤序贯治疗对多囊卵巢综合征患者行控制性超促排卵的影响 |
| 岑怡,邢长英,梁芳,曲立娟 |
| (上海市第八人民医院, 上海 200235;上海市第六人民医院, 上海 200233) |
| 摘要: |
| 目的 探讨促排汤序贯治疗对多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者行控制性超促排卵（controlled ovarian hyperstimulation，COH）的影响。方法 将60例行COH的PCOS患者随机分为观察组和对照组，每组30例。其中，观察组中超重患者19人，体质量指数（body mass index， BMI）正常患者11人；对照组中超重患者20人，BMI正常患者10人。两组患者均采用COH（拮抗剂方案）治疗，观察组在对照组基础上采用促排汤序贯治疗，两组均治疗1个COH周期。观察两组促性腺激素（gonadotropin，Gn）使用总量和时间、获卵数、受精数、受精率、优质胚胎数、优质胚胎率及卵巢过度刺激综合征发生情况。结果 观察组受精率、优质胚胎率高于对照组（P<0.05）；观察组不同BMI患者COH各项指标差异均无统计学意义（P＞0.05），但对照组中超重患者受精率显著低于BMI正常患者（P<0.05），优胚率较BMI正常患者有下降趋势（P=0.05）；超重患者中观察组受精率和优胚率均高于对照组（P<0.05）。结论 促排汤序贯可使PCOS患者在行COH中获得更高质量的胚胎，为进一步改善体外受精-胚胎移植结局奠定基础。 |
| 关键词: 多囊卵巢综合征 促排汤 序贯治疗 控制性超促排卵 |
| DOI：10.3969/j.issn.1674-070X.2021.03.026 |
| Received:October 23, 2020 |
| 基金项目:国家中医药管理局全国老中医药学术经验继承项目（国中医药人教发〔2017〕29号）；上海市卫计委中医药科研项目（2016LP011）；江苏大学医学临床科技发展基金项目（JLY20180127）。 |
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| The Effect of Sequential Method of Cupai Decoction on Patients with Polycystic Ovary Syndrome During Controlled Ovarian Hyperstimulation |
| CEN Yi,XING Changying,LIANG Fang,QU Lijuan |
| (Shanghai Eighth People's Hospital, Shanghai 200235, China;Shanghai Sixth People's Hospital, Shanghai 200233, China) |
| Abstract: |
| Objective To investigate the effect of sequential method of Cupai Decoction on patients with polycystic ovary syndrome (PCOS) during controlled ovarian hyperstimulation (COH). Methods 60 patients with PCOS who underwent COH were randomly divided into the treatment group and the control group, 30 cases in each group. In the treatment group, 19 patients were overweight and 11 patients had normal body mass index (BMI). In the control group, there were 20 overweight patients and 10 normal BMI patients. The COH (antagonist regimens) protocol was used in both groups, the treatment group was given sequential method of Cupai Decoction intervention on the basis of the control group, both groups treated in one COH period. The amount and duration of gonadotropins (Gn), the number of retrieved eggs, the number of fertilization, fertilization rate, the number of high-quality embryo, high-quality embryo rate, ovarian hyperstimulation syndrome incidence were compared between the two groups. Results The quality embryo rate and fertilization rate of the observation group were higher than those of the control group (P<0.05); there were no significant differences in COH indexes among different BMI patients in the observation group (P>0.05), but the fertilization rate of overweight patients in the control group was significantly lower than that of normal BMI patients (P<0.05), and the rate of excellent embryo had a downward trend compared with that of normal BMI patients (P=0.05); in overweight patients, the fertilization rate and embryo excellent rate in observation group were higher than those in control group (P<0.05). Conclusion Sequential method of Cupai Decoction intervention can achieve higher quality embryos in patients with PCOS undergoing COH, which lays a foundation for further improving the outcome of in vitro fertilization and embryo transfer. |
| Key words: polycystic ovary syndrome Cupai Decoction sequential method controlled ovarian hyperstimulation |
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