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毛文点,庹玲玲,齐文续,苏睿智,邓常清,邹龙.黄芪-当归不同配伍对其6种主要有效成分溶出的影响[J].湖南中医药大学学报英文版,2021,41(3):350-354.[Click to copy
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| This paper
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| 黄芪-当归不同配伍对其6种主要有效成分溶出的影响 |
| 毛文点,庹玲玲,齐文续,苏睿智,邓常清,邹龙 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察黄芪-当归不同配比对毛蕊异黄酮苷、毛蕊异黄酮、芒柄花苷、芒柄花素、阿魏酸及洋川芎内酯I含量的影响。方法 采用水提法制备黄芪、当归及黄芪-当归不同配比（5∶1、1∶1、1∶5）的药液，通过高效液相色谱法对6种主要成分分别进行线性关系、精密度、重复性及回收率检测。结果 6种对照样品线性关系良好，仪器的精密度、样品的重复性及回收率均满足标准。黄芪-当归5∶1配伍时，6种成分的溶出量均未达90%；当配伍为1∶1和1∶5时，6种成分的溶出大多高于或接近100%。结论 黄芪-当归以1∶1和1∶5配伍时可促进两者主要成分的溶出，且1∶1配伍时溶出效果最好，说明在1∶1配伍时当归对有效成分的溶出有促进作用。 |
| 关键词: 高效液相色谱法 黄芪 当归 黄酮类成分 阿魏酸 洋川芎内酯I 含量测定 |
| DOI：10.3969/j.issn.1674-070X.2021.03.005 |
| Received:January 01, 2021 |
| 基金项目:国家自然科学基金项目（81874406）。 |
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| Effects of Different Compatibility of Huangqi (Astragali Radix)-Danggui (Angelicae Sinensis Radix) on the Dissolution of 6 Main Active Components |
| MAO Wendian,TUO Lingling,QI Wenxu,SU Ruizhi,DENG Changqing,ZOU Long |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the effects of different ratios of Huangqi (Astragali Radix)-Danggui (Angelicae Sinensis Radix) on the contents of calycosin-7-O-glucoside, calycosin, ononin, formononetin, ferulic acid and senkyunolide I. Methods The medicinal solutions of Huangqi (Astragali Radix), Danggui (Angelicae Sinensis Radix) and Huangqi (Astragali Radix)-Danggui (Angelicae Sinensis Radix) in different ratios (5:1, 1:1, 1:5) were prepared by water extraction method, and the linear relationship, precision, repeatability and recovery rate of the 6 main components were tested by high performance liquid chromatography. Results The linear relationship of the 6 control samples was good, and the precision of the instrument, the repeatability of the sample and the recovery rate all met the standards. When the Huangqi (Astragali Radix)-Danggui (Angelicae Sinensis Radix) 5:1 compatibility, the dissolution of the 6 components was lower than the 90%; when the compatibility was 1:1 and 1:5, the dissolution of the 6 components was mostly higher than or close to 100%. Conclusion Huangqi (Astragali Radix)-Danggui (Angelicae Sinensis Radix) can promote the dissolution of most ingredients in the medicine when the compatibility is 1:1 and 1:5, and the dissolution effect is the best when the compatibility is 1:1, indicating that Danggui (Angelicae Sinensis Radix) can promote the dissolution of active ingredients in the 1:1 compatibility. |
| Key words: high performance liquid chromatography Huangqi (Astragali Radix) Danggui (Angelicae Sinensis Radix) flavonoids ferulic acid senkyunolide I assay |
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