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刘彩霞,邓常清.中药及复方改善血管内皮细胞氧化应激损伤的研究进展[J].湖南中医药大学学报英文版,2021,41(1):151-158.[Click to copy
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| 中药及复方改善血管内皮细胞氧化应激损伤的研究进展 |
| 刘彩霞,邓常清 |
| (湖南中医药大学医学院, 湖南 长沙 410208) |
| 摘要: |
| 动脉粥样硬化、冠心病等心血管疾病的病理生理基础是病理性血管重构，而血管内皮细胞（vascular endothelial cell，VEC）功能障碍是病理性血管重构的始动环节。VEC是锚定在基底层、与血液成分和细胞直接接触的单层细胞，是氧化应激、活性氧及其相关信号通路的作用靶点。近年来，中药在治疗心血管疾病方面卓有成效，许多中药复方、中药提取物可通过抗氧化作用保护VEC，调节心血管疾病的发生发展。本文对近年来中药及复方改善VEC氧化应激损伤的作用及其相关机制的研究进行总结，为推动其抗氧化研究及应用提供参考。 |
| 关键词: 血管内皮细胞 氧化应激 心血管疾病 中医药 |
| DOI：10.3969/j.issn.1674-070X.2021.01.029 |
| Received:June 04, 2020 |
| 基金项目:国家自然科学基金面上项目（81874406）；湖南中医药大学中西医结合一流学科开放基金项目（2019ZXYJH10）。 |
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| Research Progress on Traditional Chinese Medicine and Compound Prescription in Improving Oxidative Stress Injury of Vascular Endothelial Cells |
| LIU Caixia,DENG Changqing |
| (School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Pathological vascular remodeling (PVR) is the pathophysiological basis of cardiovascular diseases such as atherosclerosis and coronary heart disease, The initial link of PVR is vascular endothelial cell (VEC) dysfunction. VEC is monolayer endothelial cell, which is anchored in the basal layer and direct contact with components and cells from blood, as the targets of oxidative stress, reactive oxygen species and their related signaling pathways. In recent years, traditional Chinese medicine (TCM) has made great achievements in the treatment of cardiovascular diseases. Many compound prescriptions and the bioactive ingredients of TCM can protect VEC by antioxidant effects, and regulate the occurrence and development of cardiovascular diseases. In this paper, we summarized the researches on the effects of TCM and compound prescriptions on VEC oxidative stress injury and its related mechanisms in recent years, and provided a reference for promoting its antioxidant research and application. |
| Key words: vascular endothelial cell oxidative stress cardiovascular diseases traditional Chinese medicine |
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