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蒋宁兰,羊羡,陈邦第,谢汶芳.润肤止痒洗剂联合卡泊三醇软膏治疗血虚风燥型寻常型银屑病静止期的临床研究[J].湖南中医药大学学报英文版,2021,41(1):134-138.[Click to copy
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| 润肤止痒洗剂联合卡泊三醇软膏治疗血虚风燥型寻常型银屑病静止期的临床研究 |
| 蒋宁兰,羊羡,陈邦第,谢汶芳 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察润肤止痒洗剂联合卡泊三醇软膏治疗血虚风燥型寻常型银屑病静止期的临床疗效及安全性。方法 将血虚风燥型寻常型银屑病静止期患者90例按随机数字表法分为联合组、中药组及西药组，每组30例。联合组予以润肤止痒洗剂外洗联合卡泊三醇软膏外搽治疗，中药组予以润肤止痒洗剂外洗治疗，西药组予以卡泊三醇软膏外搽治疗。疗程8周。观察3组治疗前后银屑病皮损程度评分、瘙痒程度评分及不良反应，以判定临床疗效及安全性。结果 治疗后3组患者皮损面积、红斑、浸润、鳞屑评分及PASI总评分、瘙痒程度评分均较治疗前显著下降（P<0.05），且联合组各项评分均低于中药组和西药组（P<0.05），中、西药组各项评分差异无统计学意义（P>0.05）。联合组的临床疗效优于中药组、西药组（P<0.05），中、西药组间疗效差异无统计学意义（P>0.05）。结论 润肤止痒洗剂联合卡泊三醇软膏治疗血虚风燥型寻常型银屑病静止期疗效确切，优于单用卡泊三醇软膏和单用润肤止痒洗剂的疗效，且用药安全可靠。 |
| 关键词: 寻常型银屑病 血虚风燥证 润肤止痒洗剂 卡泊三醇软膏 临床研究 |
| DOI：10.3969/j.issn.1674-070X.2021.01.025 |
| Received:November 25, 2020 |
| 基金项目:湖南省科学技术厅科研项目（2017SK50301）。 |
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| Clinical Study of Runfu Zhiyang Lotion Combined with Calcipotriol Ointment in the Treatment of Resting Stage of Psoriasis Vulgaris with Blood Deficiency and Wind Dryness Type |
| JIANG Ninglan,YANG Xian,CHEN Bangdi,XIE Wenfang |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the clinical efficacy and safety of Runfu Zhiyang lotion combined with calcipotriol ointment in the treatment of resting stage of psoriasis vulgaris with blood deficiency and wind dryness type. Methods 90 patients with psoriasis vulgaris with blood deficiency and wind dryness type were randomly divided into the combined group, the traditional Chinese medicine group and the western medicine group according to random number table method, 30 cases in each group. The combined group was treated with external application of Runfu Zhiyang lotion and calcipotriol ointment, the traditional Chinese medicine group was treated with external application of Runfu Zhiyang lotion, and the western medicine group was treated with external application of calcipotriol ointment. The course of treatment was 8 weeks. The psoriasis area and severity index (PASI) score, pruritus score and adverse reactions were observed before and after treatment in the three groups to determine the clinical efficacy and safety. Results After treatment, the lesions area, erythema, infiltration, flaking score, PASI total score and pruritus score in 3 groups were significantly decreased compared with before treatment (P<0.05), the scores of combined group were lower than the traditional Chinese medicine group and western medicine group (P<0.05), there was no significant difference between the traditional Chinese medicine group and the western medicine group (P>0.05). The clinical efficacy of the combined treatment group was better than the traditional Chinese medicine group and the western medicine group (P<0.05), and there was no statistical significance in the efficacy difference between the traditional Chinese medicine group and the western medicine group (P>0.05). Conclusion The efficacy of Runfu Zhiyang lotion combined with calcipotriol ointment in the treatment of psoriasis vulgaris with blood deficiency and wind dryness type at rest stage is better than that of calcipotriol ointment and Runfu Zhiyang lotion alone, and the medication is safe and reliable. |
| Key words: psoriasis vulgaris blood deficiency and wind dryness type Runfu Zhiyang lotion calcipotriol ointment clinical research |
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