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林秀莲,王卫,覃丽,李凯,戴爱国,廖端芳.SARS-CoV-2与SARS-CoV的主要生物学特性差异对研发防治COVID-19药物的启示[J].湖南中医药大学学报英文版,2020,40(11):1413-1420.[Click to copy
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| This paper
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| SARS-CoV-2与SARS-CoV的主要生物学特性差异对研发防治COVID-19药物的启示 |
| 林秀莲,王卫,覃丽,李凯,戴爱国,廖端芳 |
| (湘产大宗药材品质评价湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学干细胞中药调控与应用实验室, 湖南 长沙 410208;湖南中医药大学医学院呼吸疾病研究室, 湖南 长沙 410208) |
| 摘要: |
| 本文分析了2019年新型冠状病毒（SARS-CoV-2）的基本构成、遗传性状、受体特征、蛋白切割位点、进入宿主细胞机制及引起细胞因子风暴等主要生物学特征，并与2003年“非典”病毒（SARS-CoV）进行比较，以期对研发防治COVID-19药物有所启示。 |
| 关键词: SARS-CoV-2 SARS-CoV 生物学特性 致病原理 药物研发 |
| DOI：10.3969/j.issn.1674-070X.2020.11.023 |
| Received:September 18, 2020 |
| 基金项目:湖南省教育厅重大病毒感染性疾病防治科技攻关专项（湘财教指〔2020〕17号）；湖南省中医药防治新冠肺炎科研攻关课题（KYGG06，湘中医药〔2020〕5号）。 |
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| Implications of Biological Differences of SARS-COV-2 and SARS-COV for the Development of Drugs Against COVID-19 |
| LIN Xiulian,WANG Wei,QIN Li,LI Kai,DAI Aiguo,LIAO Duanfang |
| (Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan Universityof Chinese Medicine, Changsha, Hunan 410208, China;Division of Stem Cell Regulation and Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Department of Respiratory Diseases, School of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| This paper tried to have an in-depth analysis of its basic composition, genetic traits, receptor characteristics, protein cleavage sites, mechanism of entering host cells and characteristics of cytokine storm of this novel coronavirus SARS-CoV-2, and its differences with SARS virus (SARS-CoV) in 2003, to provide some inspiration for the research and development of drugs for prevention and treatment of COVID-19. |
| Key words: SARS-COV-2 SARS-CoV biological characteristics COVID-19 pathogenic mechanism drug development |
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