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邱馨锐,闫小宁,陈璐,李文彬.基于数据挖掘探讨中药面膜治疗痤疮用药规律[J].湖南中医药大学学报英文版,2020,40(11):1379-1383.[Click to copy
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| 基于数据挖掘探讨中药面膜治疗痤疮用药规律 |
| 邱馨锐,闫小宁,陈璐,李文彬 |
| (陕西中医药大学第一临床医学院, 陕西 咸阳 712046;陕西省中医医院皮肤科, 陕西 西安 710004) |
| 摘要: |
| 目的 分析并总结中药面膜治疗痤疮的用药规律。方法 检索PubMed、中国期刊全文数据库、万方数据库、维普数据库、中国生物医学文献数据库中，以中药面膜治疗痤疮的临床文献，检索时限均为建库至2020年3月，采用Excel 2016软件建立中药数据库，采用Clementine 12.0以及SPSS 25.0软件中的聚类分析和关联规则分析方法，分析用药规律。结果 纳入237篇论文，发现237条处方，涉及155味中药，中药使用总频次为1 843次。治疗痤疮面膜所用中药以性寒味苦为主，且多归肝经、胃经、肺经，通过关联性分析得到置信度最高的关联群是黄芩-大黄，支持度最高的关联群是大黄-硫黄，通过聚类分析得出10个核心药对。结论 中药面膜组方以苦寒之药清热解毒为主，兼以疏调气血、消瘀散结。 |
| 关键词: 痤疮 中药面膜 外治法 用药规律 数据挖掘 |
| DOI：10.3969/j.issn.1674-070X.2020.11.016 |
| Received:June 16, 2020 |
| 基金项目:国家重点研发计划项目（2018YFC1705303）；陕西省重点研发计划项目（2019SF-312，2019ZDLSF04-08）。 |
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| Based on Data Mining to Explore the Medication Rules of Chinese Materia Medica Mask in the Treatment of Acne |
| QIU Xinrui,YAN Xiaoning,CHEN Lu,LI Wenbin |
| (The First Clinical Medical College of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China;Dermatology Department, Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi 710004, China) |
| Abstract: |
| Objective To analyze and summarize the medication rule of Chinese materia medica mask treatment of acne. Methods Clinical papers on Chinese materia medica mask treatment of acne published from the establishment of the database to March 2020 were retrieved from databases of PubMed, CNKI, Wanfang Database, VIP, CBM, Web of Science and Embase. Excel 2016 software was used to establish a database of Chinese materia medica, and the cluster analysis and association rule analysis methods in Clementine 12.0 and SPSS 25.0 software were used to analyze the medication rules. Results A total of 237 papers were included, and 237 prescriptions were found, involving 155 Chinese materia medica, with a total frequency of 1 843 times. The herbs in the treatment of acne were mainly cold in nature and bitter in flavor. The channel tropism was mainly liver meridian, stomach meridian and lung meridian. The analysis of association rules showed that the association group with the highest confidence was Radix Scutellariae-Radix et Rhizoma Rhei, and the association group with the highest support was Radix et Rhizoma Rhei-Sulfur. The clustering analysis figured out 10 pairs of essential herbs. Conclusion The prescription of Chinese materia medica mask was mainly bitter and cold herbs for clearing heat and removing toxin, and also for soothing and regulating Qi and blood, resolving blood stasis and dissipating mass. |
| Key words: acne Chinese materia medica mask external treatment medication rules data mining |
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