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吕山河,胡碧浓,黄梓铭,吴霞,张雨辰,许明,邓石峰,瞿启叡,艾坤,张泓.电针对骶上脊髓损伤大鼠膀胱尿流动力学和逼尿肌肌电图振幅的影响[J].湖南中医药大学学报英文版,2020,40(11):1355-1360.[Click to copy
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| 电针对骶上脊髓损伤大鼠膀胱尿流动力学和逼尿肌肌电图振幅的影响 |
| 吕山河,胡碧浓,黄梓铭,吴霞,张雨辰,许明,邓石峰,瞿启叡,艾坤,张泓 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察电针对SD大鼠骶上脊髓损伤后神经源性膀胱尿流动力学以及逼尿肌肌电图振幅的影响。方法 将36只雌性SD大鼠随机分成空白组、模型组、治疗组，每组12只。治疗组和模型组大鼠脊髓横断部位为T10节段，在采用Hassan Shaker脊髓横断法基础上加以改良制作全横断大鼠模型。脊髓休克期14 d后，给予治疗组电针“三阴交”“次髎”“中极”穴，模型组只捆绑不治疗，空白组不做任何处理。疗程结束后，进行尿流动力学以及逼尿肌肌电图振幅的测定。结果 与空白组相比，模型组的膀胱漏尿点压力明显增高，模型组和治疗组的膀胱灌注量明显增多、膀胱灌注时间明显增长、膀胱逼尿肌肌电图振幅明显降低，差异均有统计学意义（P<0.05）；与模型组相比，治疗组的膀胱漏尿点压力明显降低、膀胱灌注量明显减少、膀胱灌注时间明显缩短、逼尿肌肌电图振幅明显增高，差异均有统计学意义（P<0.05）。结论 电针治疗可改善大鼠骶上脊髓损伤后神经源性膀胱的尿流动力学，提高逼尿肌肌电图振幅。 |
| 关键词: 脊髓损伤 神经源性膀胱 电针 尿流动力学 逼尿肌 肌电图 |
| DOI：10.3969/j.issn.1674-070X.2020.11.012 |
| Received:June 15, 2020 |
| 基金项目:国家自然科学基金面上项目（81874510）；湖南省自然科学基金青年项目（82019JJ50437）；湖南省中医药管理局科研计划项目重点课题（8201704）。 |
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| Effects of Electroacupuncture on Bladder Urodynamics and Detrusor Electromyography Amplitude in Rats with Suprasacral Spinal Cord Injury |
| LYU Shanhe,HU Binong,HUANG Ziming,WU Xia,ZHANG Yuchen,XU Ming,DENG Shifeng,QU Qirui,AI Kun,ZHANG Hong |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the effects of electroacupuncture on neurogenic bladder urodynamics and detrusor electromyogram amplitude after suprasacral spinal cord injury in SD rats. Methods Thirty-six female SD rats were randomly divided into a blank group, a model group and a treatment group, with 12 rats in each group. The rats in the treatment group and the model group were modified to make the fully transected rat model based on Hassan Shaker's spinal cord transection method at T10 level of spinal cord. Fourteen days after spinal cord shock, the treatment group was given electroacupuncture at points Sanyinjiao (SP6), Ciliao (BL32), and Zhongji (RN3). The model group was only bound without treatment, and the blank group was not treated. After the treatment, the urodynamic synchronous detrusor electromyogram was measured to observe the effect of electroacupuncture on neurogenic bladder urodynamic and detrusor electromyogram amplitude after supracral spinal cord in SD rats. Results Compared with the blank group, the bladder leak pressure in the model group and the treatment group was significantly increased, and the bladder perfusion volume was significantly increased. The bladder perfusion time was increased significantly, and the electromyogram amplitude of bladder detrusor was decreased significantly. The difference was statistically significant (P<0.05). Compared with the model group, the pressure of bladder leak point in the treatment group was significantly reduced, and the amount of bladder perfusion was significantly reduced. The bladder perfusion time was significantly shortened, and the electromyogram amplitude of detrusor muscle was significantly increased. The difference was statistically significant (P<0.05). Conclusion Electroacupuncture can improve the urodynamics of neurogenic bladder and increase the amplitude of detrusor electromyography after suprasacral spinal cord injury in rats. |
| Key words: spinal cord injury neurogenic bladder electroacupuncture urodynamic detrusor electromyography |
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