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蒲科婷,王志琪,李耀伟,邓凯文,张序晴,丛梦静,彭兰,曾嵘.基于心肌细胞能量代谢及钙稳态探讨附子作用机制[J].湖南中医药大学学报英文版,2020,40(10):1293-1297.[Click to copy
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| 基于心肌细胞能量代谢及钙稳态探讨附子作用机制 |
| 蒲科婷,王志琪,李耀伟,邓凯文,张序晴,丛梦静,彭兰,曾嵘 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208;湖南省中药饮片标准化及功能工程中心, 湖南 长沙 410208;湖南中医药大学研究生院, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 附子是中医临床常用的温阳药物，可用于治疗心阳虚证，但因其性味峻猛毒性剧烈而未广泛安全运用于临床，故探明其温心阳机制及其毒效关系可促进其安全有效用药。本文以阳气之温煦推动作用的相关机制为切入点，阐述了附子温心阳作用与改善能量代谢及调节钙稳态作用的关系，来探究附子温阳作用及其机制，以期为科学指导附子临床合理使用提供依据。 |
| 关键词: 附子 温心阳 心肌细胞 AMPK通路 钙调蛋白 能量代谢 |
| DOI：10.3969/j.issn.1674-070X.2020.10.024 |
| Received:December 29, 2019 |
| 基金项目:国家自然科学基金项目（81503492）；湖南省自然科学基金项目（2015JJ6079）；湖南省教育厅科学研究项目（19A376）；国家级大学生创新训练计划项目（201910541019）；湖南省大学生创新项目（湘教通〔2019〕100-1669）。 |
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| Study on the Action Mechanism of Radix Aconiti Lateralis Preparata Based on Energy Metabolism and Calcium Homeostasis of Myocardial Cell |
| PU Keting,WANG Zhiqi,LI Yaowei,DENG Kaiwen,ZHANG Xuqing,CONG Mengjing,PENG Lan,ZENG Rong |
| (College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Center for Standardization and Functional Engineering of Chinese Herbal Pieces, Changsha, Hunan 410208, China;Graduate School of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Radix Aconiti Lateralis Preparata is a kind of Chinese materia medica for warming Yang, and it can be used to treat heart Yang deficiency and other syndromes. Since its strong nature and toxicity, it is difficult to be widely and safely used in clinical practice. Therefore, this paper discussed its mechanism of warming heart Yang and the relationship between the toxicity and effect to promote its safe and effective application. In order to provide the basis for guiding the clinical rational use of Radix Aconiti Lateralis Preparata, this paper took the relevant mechanism of warming promotion of Yang Qi as the breakthrough point, and discussed the relationship between the effect of warming heart Yang of Radix Aconiti Lateralis Preparata and the improvement of energy metabolism and the regulation of calcium homeostasis, so as to explore the warming Yang effect of Radix Aconiti Lateralis Preparata and its mechanism. |
| Key words: Radix Aconiti Lateralis Preparata warming heart Yang AMPK pathway calmodulin myocardial cell energy metabolism |
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