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吴伟璇,韦芳宁,王济.基于数据挖掘分析王琦教授治疗少弱精子症的用药规律[J].湖南中医药大学学报英文版,2020,40(10):1276-1279.[Click to copy
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| 基于数据挖掘分析王琦教授治疗少弱精子症的用药规律 |
| 吴伟璇,韦芳宁,王济 |
| (广州中医药大学第二临床医学院, 广东 广州 510504;广东省中医院, 广东 广州 510120;北京中医药大学国家中医体质与治未病研究院, 北京 100029) |
| 摘要: |
| 目的 分析王琦教授治疗少弱精子症的方剂用药规律，以期为中医治疗少弱精子症用药提供参考和研究思路。方法 收集王琦教授2018年门诊所诊治少弱精子症病历，应用中医传承辅助平台（V2.5）软件，构建数据库，对用药频次、四气、五味、归经分布、关联规则等进行统计分析。结果 对病历所载的57首方剂进行分析，共纳入94味中药。频次前3位的常用药物是巴戟天、桑椹、菟丝子；辛甘、平温药物使用频次较高；药物归经分析发现归肝、肾经的药物最多，其次是脾、肺、胃经；常用药物组合出现频次≥25的组合共35组，前3位的组合分别是菟丝子-巴戟天、桑椹-巴戟天、菟丝子-桑椹；聚类提炼得到6对核心组合，3个新方。结论 王琦教授从精室论治男性不育症，强调“肾虚夹湿热瘀毒虫”，倡导主病主方专药的学术思想，用药多以补肾清利、活血解毒为主。 |
| 关键词: 少弱精子症 男性不育症 王琦 中医传承辅助平台 用药规律 |
| DOI：10.3969/j.issn.1674-070X.2020.10.020 |
| Received:December 05, 2019 |
| 基金项目:广东省科学技术厅-广东省中医药科学院联合科研项目（2014A020221082）；广东省中医院王琦学术经验传承工作室（E43713）。 |
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| Analysis of Professor WANG Qi's Medication Law for Oligoasthenospermia Based on Data Mining |
| WU Weixuan,WEI Fangning,WANG Ji |
| (The Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510504, China;Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou, Guangdong 510120, China;National Institute of traditional Chinese Medicine Consititution and Preventive Medicine, Beiing University of Chinese Medicine, Beijing 100029, China) |
| Abstract: |
| Objective To analyze Professor WANG Qi's medication law of prescription for oligozoospermia in order to provide reference and research ideas for the treatment of oligozoospermia with traditional Chinese medicine (TCM). Methods We collected the medical records of Professor WANG Qi's outpatient clinic with diagnosis and treatment of oligoasthenospermia in 2018, and applied traditional Chinese medicine inheritance support system (V2.5) to establish a database. The data was analyzed in terms of frequency statistics of four natures, five flavors, channel tropism, association rules and clustering. Results The 57 prescriptions in the medical records were analyzed, and a total of 94 Chinese materia medica were included. The top 3 commonly used herbs were Radix Morindae Officinalis, Fructus Mori, and Semen Cuscutae. The pungent and sweet, neutral and warm herbs were frequently used. For channel tropism, most herbs were in the liver and kidney channel, followed by the spleen, lung and stomach. A total of 35 groups of common herb pairs with frequency ≥ 25. The top 3 herb pairs were Semen Cuscutae-Radix Morindae Officinalis, Fructus Mori-Radix Morindae Officinalis, Semen Cuscutae-Fructus Mori; 6 pairs of core combinations and 3 new prescriptions were obtained from clustering. Conclusion Professor WANG Qi treats male infertility from essence chamber, emphasizes "kidney deficiency with dampness heat, stasis, insect toxin", and advocates the academic thoughts of primary disease with primary prescription and specialized herbs. The herbs to tonify kidney, clear and drain, promote blood circulation and detoxicate are mainly used. |
| Key words: oligoasthenospermia male infertility WANG Qi traditional Chinese medicine inheritance support system medication law |
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