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李洁,李新纯,李杰,刘畅,徐乐乐,杨萍.脑心同治针刺法联合利培酮对精神分裂症攻击行为及认知功能的临床疗效观察[J].湖南中医药大学学报英文版,2020,40(10):1244-1248.[Click to copy
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| 脑心同治针刺法联合利培酮对精神分裂症攻击行为及认知功能的临床疗效观察 |
| 李洁,李新纯,李杰,刘畅,徐乐乐,杨萍 |
| (湖南中医药大学临床医学院, 湖南 长沙 410208;湖南省脑科医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察脑心同治针刺法联合利培酮治疗精神分裂症伴发攻击行为患者的临床疗效、安全性及对认知功能的改善。方法 将117例伴发攻击行为的精神分裂症患者随机分为观察组（针刺+利培酮组）59例和对照组（利培酮组）58例，治疗6周后，观察两组治疗前后阴性及阳性症状量表（positive and negative syndrome scale，PANSS）评分、药物不良反应量表（treatment emergent symptom scale，TESS）评分、外显攻击行为量表（modified overt aggression scale，MOAS）评分、蒙特利尔认知评估量表（Montreal cognitive assessment，MOCA）评分的变化。结果 治疗后两组PANSS总分、MOAS总分较治疗前均明显下降（P<0.05），且观察组较对照组下降显著（P<0.05）；治疗后观察组TESS评分明显低于对照组（P<0.05）；比较治疗前后MOCA评分，治疗后两组视空间与执行能力、命名、注意力、语言能力及定向力均有明显改善（P<0.05），而观察组的注意力、语言能力及定向力较对照组改善更明显（P<0.05），且可以提高延迟记忆能力（P<0.05）。结论 脑心同治针刺法联合利培酮治疗能有效改善精神分裂症患者的攻击行为，不良反应少，且具有改善注意力、语言能力、记忆力、视空间及执行能力的优势。 |
| 关键词: 精神分裂症 攻击行为 脑心同治 针刺 利培酮 认知功能 |
| DOI：10.3969/j.issn.1674-070X.2020.10.013 |
| Received:April 06, 2020 |
| 基金项目:国家自然科学基金项目（81603512，81673962）；湖南省中医药管理局课题（201912）；湖南省自然科学基金项目（2019JJ80028）；湖南省精神行为障碍临床研究中心（2018SK7002）。 |
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| Clinical Observation on the Effect of Acupuncture with Brain-Heart Concurrent Regulation Therapy with Risperidone on Aggressive Behavior and Cognitive Function of Schizophrenia |
| LI Jie,LI Xinchun,LI Jie,LIU Chang,XU Lele,YANG Ping |
| (Clinical School of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Brain Hospital, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical efficacy, safety, and improvement of cognitive function in patients with schizophrenia with aggressive behavior by acupuncture with brain-heart concurrent regulation therapy combined with risperidone. Methods A total of 117 schizophrenia patients with aggressive behavior were randomly divided into an observation group (acupuncture + risperidone group) of 59 cases and a control group (risperidone group) of 58 cases. After 6 weeks of treatment, the positive and negative syndrome scale (PANSS) score, the changes of treatment emergent symptom scale (TESS) score, the modified overt aggression scale (MOAS) score, the montreal cognitive assessment (MOCA) score of the 2 groups before and after the treatment were observed. Results After treatment, the total scores of PANSS and MOAS in the 2 groups were decreased compared with before the treatment (P<0.01), while the observation group was significantly decreased than the control group (P<0.05); The total scores of TESS was obviously lower in the observation group than the control group after treatment (P<0.01). When comparing MOCA scores before and after treatment, the scores of visual space and execution ability, attention, naming, language competence and orientation were significantly improved in the 2 groups (P<0.05), while the observation group had significantly higher scores than the control group in attention, language competence and orientation (P<0.05), and the delayed recall improved obviously (P<0.05). Conclusion Acupuncture with brain-heart concurrent regulation therapy combined with risperidone can improve the clinical effect for attack behavior in schizophrenia, with little side effect, and it has the advantages of improving attention, language competence, memory, visual space and executive ability. |
| Key words: schizophrenia aggressive behavior brain-heart concurrent regulation therapy acupuncture risperidone cognitive function |
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