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罗江.天麻钩藤汤联合硝苯地平控释片治疗原发性高血压肝阳上亢证疗效及安全性研究[J].湖南中医药大学学报英文版,2020,40(8):996-999.[Click to copy
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| 天麻钩藤汤联合硝苯地平控释片治疗原发性高血压肝阳上亢证疗效及安全性研究 |
| 罗江 |
| (清华大学玉泉医院治未病科, 北京 100040) |
| 摘要: |
| 目的 探究天麻钩藤汤结合硝苯地平控释片治疗原发性高血压肝阳上亢证临床疗效及安全性。方法 本次研究纳入我院2018年12月至2019年12月收治的原发性高血压肝阳上亢证患者62例，采取随机数字表法将纳入患者分为两组，对照组患者（31例）给予硝苯地平控释片治疗，观察组患者（31例）给予硝苯地平控释片联合天麻钩藤汤治疗，连续治疗2个月时间，比较两组患者临床治疗效果、治疗前后患者血压水平、中医症状积分、血管内皮素-1（ET-1）、一氧化氮（NO）水平变化及治疗后不良反应情况。结果 对照组患者治疗有效率（80.65%）低于观察组（96.77%）(P<0.05)，差异具有统计学意义；治疗后两组患者血压、ET-1和NO水平、中医症状积分均改善，观察组指标均优于对照组（P<0.05）；观察组与对照组患者不良反应率分别为6.45%、3.23%，比较差异无统计学意义（P>0.05）。结论 天麻钩藤汤结合硝苯地平控释片治疗原发性高血压肝阳上亢证临床疗效显著，患者症状改善，血压稳定，不良反应率低，安全可靠。 |
| 关键词: 原发性高血压 肝阳上亢证 天麻钩藤汤 硝苯地平控释片 血压 中医症状积分 不良反应 |
| DOI：10.3969/j.issn.1674-070X.2020.08.016 |
| Received:February 24, 2020 |
| 基金项目:孙光荣国医大师工作室传承项目。 |
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| Study on Efficacy and Safety of Tianma Gouteng Decoction Combined with Nifedipine Controlled-Release Tablets in the Treatment of Hyperactivity of Liver-Yang in Patients with Essential Hypertension |
| LUO Jiang |
| (Preventive Treatment of Disease Department, Tsinghua University Yuquan Hospital, Beijing 100040, China) |
| Abstract: |
| Objective To explore the clinical efficacy and safety of Tianma Gouteng Decoction combined with nifedipine controlled-release tablets in the treatment of hyperactivity of liver-Yang in patients with essential hypertension. Methods This study included 62 cases of patients with primary hypertension of liver Yang syndrome from December 2018 to December 2019 in our hospital. The random number table method was used to divide the patients into 2 groups. The control group (31 cases) was treated with nifedipine controlled-release tablets. The observation group (31 cases) was given nifedipine controlled-release tablets combined with Tianma Gouteng Decoction. The 2 groups was treated for consecutive 2 months. The clinical treatment effect, changes of blood pressure, TCM symptom scores, endothelin-1 (ET-1) and nitric oxide (NO) levels before and after treatment, and adverse reactions were compared between the 2 groups. Results The effective rate was 80.65% in the control group, which was lower than 96.77% in the observation group (P<0.05), which was statistically significant. After treatment, the blood pressure, ET-1, NO level, TCM symptom score in the 2 group were all improved, and the indexes of the observation group were all better than those of the control group (P<0.05). The adverse reaction rates of patients in the observation group and the control group were 6.45% and 3.23%, respectively, with no statistically significant difference between the 2 groups (P>0.05). Conclusion Tianma Gouteng Decoction combined with nifediping controlled-release tablets has a significant clinical effect in the treatment of primary hypertension with hyperactivity of liver-Yang, which is safe and reliable with improved symptoms, stable blood pressure and low adverse reaction rate. |
| Key words: essential hypertension syndrome of hyperactivity of liver Yang Tianma Gouteng Decoction nifedipine controlled release tablet blood pressure TCM symptom score adverse reactions |
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