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冯高飞,陈若,易舒婧,彭昭文,刘鹏,钟元涛,涂轩,尤海玲,胡凯文.升清降浊汤联合华蟾素注射液腹腔灌注治疗恶性腹水的疗效观察[J].湖南中医药大学学报英文版,2020,40(4):498-502.[Click to copy
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| 升清降浊汤联合华蟾素注射液腹腔灌注治疗恶性腹水的疗效观察 |
| 冯高飞,陈若,易舒婧,彭昭文,刘鹏,钟元涛,涂轩,尤海玲,胡凯文 |
| (北京中医药大学深圳医院[龙岗], 广东 深圳 518172;北京中医药大学东方医院, 北京 100078) |
| 摘要: |
| 目的 观察升清降浊汤口服联合华蟾素注射液腹腔灌注治疗湿热型恶性腹水的临床疗效。方法 120例局部辨证为湿热型的恶性腹水患者随机分为观察组60例和对照组60例，对照组采用华蟾素注射液腹腔灌注，观察组在此基础上加用升清降浊汤口服，共治疗4周。4周后观察两组患者临床疗效、中医症状改善情况、卡氏功能状态（Karnofsky performance status，KPS）评分、腹水缺氧诱导因子-1α（hypoxia inducible factor-1α，HIF-1α）、血管内皮生长因子（vascular endothelial growth factor，VEGF）表达水平及血液T淋巴细胞亚群表达水平。结果 观察组患者在临床疗效、中医临床症状及KPS评分改善方面均优于对照组（P<0.01），同时观察组患者腹水HIF-1α、VEGF表达水平也较对照组有不同程度的下降（P<0.01，P<0.05）。观察组患者血液T细胞亚型CD3+、CD4+及CD4+/CD8+比值均明显高于对照组，差异有统计学意义（P<0.01，P<0.05）。结论 升清降浊汤口服联合华蟾素注射液腹腔灌注治疗局部辨证为湿热型的恶性腹水较单独华蟾素注射液效果好，其作用机制可能为通过降低HIF-1α、VEGF表达，提升CD3+、CD4+及CD4+/CD8+比值来实现。 |
| 关键词: 恶性腹水 升清降浊汤 华蟾素注射液 腹腔灌注 临床疗效 |
| DOI：10.3969/j.issn.1674-070X.2020.04.023 |
| Received:February 10, 2020 |
| 基金项目:广东省中医药局中医药科研项目（20201299）；北京中医药大学科研项目（青年教师类2018-BUCMXJKY015）。 |
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| Efficacy Observation on Shenqing Jiangzhuo Decoction Combined with Cinobufacin Injection in the Treatment of Malignant Ascites |
| FENG Gaofei,CHEN Ruo,YI Shujing,PENG Zhaowen,LIU Peng,ZHONG Yuantao,TU Xuan,YOU Hailing,HU Kaiwen |
| (Shenzhen Hospital(Longgang) of Beijing University of Chinese Medicine, Shenzhen, Guangdong 518172, China;Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China) |
| Abstract: |
| Objective To observe the clinical effect of Shenqing Jiangzhuo Decoction (SQJZD) combined with Cinobufacin Injection in the treatment of malignant ascites of damp heat syndrome. Methods A total of 120 cases of malignant ascites with locally syndrome differentiation of damp heat syndrome were randomly divided into an observation group (60 cases) and a control group (60 cases). The control group was infused with Cinobufacin Injection intraperitoneally, and the observation group was treated with SQJZD on the basis of the perfusion for 4 weeks. After 4 weeks, the clinical effect, the improvement of traditional Chinese medicine (TCM) symptoms, Karnofsky performance status (KPS) score, the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in ascites and the expression of T-lymphocyte subsets of the 2 groups were observed. Results The observation group was superior to the control group in clinical efficacy, TCM symptom improvement and KPS score (P<0.01). At the same time, the expression of HIF-1 α and VEGF in the observation group were decreased with various degress than that in the control group (P<0.01, P<0.05). The expression of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly higher than that in the control group, and the difference was statistically significant (P<0.01, P<0.05). Conclusion The therapeutic effect of SQJZD combined with Cinobufacin Injection is better than that of Cinobufacin Injection alone in the treatment of malignant ascites with local syndrome differentiation of damp heat syndrome. Its mechanism may be achieved by reducing the expression of HIF-1 α and VEGF, and increasing the levels of CD3+, CD4+, and CD4+/CD8+. |
| Key words: malignant ascites Shenqing Jiangzhuo Decoction Cinobufacin Injection clinical effect |
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