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徐文静,陈其华.肾气丸对前列腺癌下尿路症状的临床疗效观察[J].湖南中医药大学学报英文版,2020,40(3):369-372.[Click to copy
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| 肾气丸对前列腺癌下尿路症状的临床疗效观察 |
| 徐文静,陈其华 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察肾气丸对前列腺癌下尿路症状的临床疗效。方法 选取40例病理诊断为前列腺癌且伴有不同程度下尿路症状的患者随机分为治疗组与对照组，每组20例。对照组采用醋酸戈舍瑞林缓释植入剂腹前壁皮下注射及比卡鲁胺片口服，治疗组在同对照组治疗的同时服用肾气丸（改丸为汤）。疗程3个月。观测两组治疗前后患者膀胱残余尿量、最大尿流率、国际前列腺症状评分（IPSS）、生活质量评分（QOL）、血清总前列腺特异性抗原（tPSA）及尿常规。结果 治疗后两组患者的膀胱残余尿量减少、IPSS评分及QOL评分较治疗前降低、血清tPSA值下降明显、最大尿流率增加（P<0.05）；其中，血清tPSA值在治疗后组间差异无统计学意义（P>0.05），其余各项指标均治疗组疗效优于对照组（P<0.05）。治疗组治疗后血尿率显著降低（P<0.05），对照组血尿率较治疗前无明显变化（P>0.05）。结论 肾气丸能明显减轻前列腺癌患者下尿路症状，提高患者的生活质量，值得临床推广。 |
| 关键词: 前列腺癌 下尿路症状 肾气丸 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2020.03.024 |
| Received:September 05, 2019 |
| 基金项目:湖南省男性疾病中医临床医学研究中心（2018SK4012）；湖南省中医药科研计划项目（201732）；湖南中医药大学研究生创新课题（2018CX16）。 |
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| Efficacy Observation on Shenqi Pills on Lower Urinary Tract Symptoms of Prostate Cancer |
| XU Wenjing,CHEN Qihua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical effects of Shenqi Pills on lower urinary tract symptoms of prostate cancer. Methods A total of 40 cases with pathological diagnosis of prostate cancer with different degrees of lower urinary tract symptoms were randomly divided into a treatment group and a control group, with 20 cases in each group. The control group was treated with subcutaneous injection of goserelin acetate sustained-release depot in the anterior wall of the abdomen, and oral administration of bicalutamide tablets. On the basis of this, the treatment group was given Shenqi Pills (modified pills into decoction), for 3 months as a treatment course. Bladder residual urine volume, maximum urine flow rate, international prostate symptom score (IPSS), quality of life(QOL) score, serum total prostate-specific antigen (tPSA) and urine routine were observed. Results After treatment, the residual urine volume of the bladder was reduced. The IPSS score and QOL score were reduced than before. The serum tPSA value was significantly decreased, and the maximum urine flow rate was increased (P<0.05). Among them, the serum tPSA value had no significant difference between the two groups after treatment (P>0.05), and the other indicators showed that the therapeutic effect of the treatment group was better than that of the control group (P<0.05). After treatment, the rate of hematuria in the treatment group decreased, and it did not change significantly in the control group (P>0.05). Conclusion Shenqi Pills can significantly reduce the various lower urinary tract symptoms of prostate cancer patients, and improve their quality of life, which is worthy of clinical promotion. |
| Key words: prostate cancer lower urinary tract symptoms Shenqi Pills clinical observation |
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