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李姣,易星星,邱冉冉.护卵汤对围绝经期综合征心肾不交型患者的疗效观察与作用机制研究[J].湖南中医药大学学报英文版,2020,40(2):232-235.[Click to copy
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| 护卵汤对围绝经期综合征心肾不交型患者的疗效观察与作用机制研究 |
| 李姣,易星星,邱冉冉 |
| (湖南中医药大学第一附属医院妇产科, 湖南 长沙 410007) |
| 摘要: |
| 目的 探讨护卵汤对心肾不交型围绝经期综合征患者性激素水平、Kupperman评分及骨密度水平的影响。方法 选择2016年3月至2017年4月80例心肾不交型围绝经期综合征患者进行研究。采用随机数字表法将患者分为2组，每组40例。对照组给予替勃龙片，观察组在此基础上加以护卵汤。比较两组患者临床疗效、性激素水平、Kupperman评分、骨密度水平及安全性指标。结果 观察组患者总有效率为90.0%，显著高于对照组的67.5%；治疗后两组患者FSH、LH水平及Kupperman评分均明显下降，但观察组下降幅度更大（P<0.05）；治疗后两组患者E2、腰椎1-4节及左股骨骨密度水平均明显升高，但观察组升高更明显（P<0.05）。对照组出现2例（5.0%）不良反应，与观察组的1例（2.5%）差异无统计学意义（P>0.05）。结论 护卵汤联合替勃龙较单独使用替勃龙可明显提高心肾不交型围绝经期综合征疗效，改善性激素和骨密度水平，降低Kupperman评分，且具有较高的安全性。 |
| 关键词: 护卵汤 心肾不交 围绝经期综合征 疗效 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2020.02.023 |
| Received:October 18, 2019 |
| 基金项目:2017年度湖南省自然科学基金立项项目（2017JJ3243）。 |
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| Study on Therapeutic Effects and Action Mechanism of Huluan Decoction in the Treatment of Patients with Peri-menopausal Syndrome of Disharmony Between Heart and Kidney |
| LI Jiao,YI Xingxing,QIU Ranran |
| (Department of Obstetrics and Gynecology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To investigate the effects of Huluan Decoction on sex hormone level, Kupperman score and bone mineral density in patients with peri-menopausal syndrome of disharmony between heart and kidney. Methods A total of 80 patients with peri-menopausal syndrome of disharmony between heart and kidney were selected from March 2016 to April 2017. Patients were divided into 2 groups using a random number table method, with 40 cases in each group. The control group was given tibolone tablets, and the observation group was given Huluan Decoction on this basis. Clinical efficacy, sex hormone levels, Kupperman score, bone mineral density and safety indicators were compared between the 2 groups. Results The total effective rate of the observation group was 90.00%, which was significantly higher than that of the control group (67.50%) (P<0.05). After treatment, the FSH, LH levels and Kupperman scores of the 2 groups decreased significantly, but the observation group decreased more. After treatment, E2, lumbar vertebrae 1-4 knots and left femur bone mineral density of the 2 groups increased significantly, but the observation group increased more significantly (P<0.05). There were 2 cases (5.00%) of adverse reactions in the control group, and there was no significant difference between the 2 groups when compared with 1 case (2.5%) in the observation group (P>0.05). Conclusion The combination of Huluan Decoction and tibolone can significantly improve the efficacy of peri-menopausal syndrome, improve sex hormone levels, improve bone mineral density, and has higher safety than tibolone alone. |
| Key words: Huluan Decoction disharmony between heart and kidney peri-menopausal syndrome efficacy mechanism of action |
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