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冯君,王伟松,曾凡玉,谭彩,刘建和.温阳利水法联合西药治疗心肾综合征临床疗效及对炎症因子影响的Meta分析[J].湖南中医药大学学报英文版,2020,40(2):180-187.[Click to copy
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| 温阳利水法联合西药治疗心肾综合征临床疗效及对炎症因子影响的Meta分析 |
| 冯君,王伟松,曾凡玉,谭彩,刘建和 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 通过Meta分析评价温阳利水法联合西药治疗心肾综合征临床疗效和对常见炎症因子的影响。方法 通过计算机检索5个中英文数据库（中国知网、万方数据、中国生物医学文献数据库、Pubmed、Web of science），筛选建库至2019年7月前公开发表的温阳利水类中药联合西药治疗心肾综合征的随机对照临床研究，经筛选后最终纳入13个研究，共计1 268例患者，采用Revman5.3软件进行统计分析。结果 温阳利水法联合西药治疗心肾综合征在总有效率、提高左室射血分数、减小左室舒张末内径、降低N端脑利钠肽前体、降低血清肌酐、尿素氮和提高肾小球滤过率及改善炎症反应方面均优于单纯西药治疗。结论 在西医常规治疗心肾综合征基础上联合温阳利水类中药可明显改善其疗效，其机制可能与减轻炎症反应相关，但现有研究质量较低，纳入病例数量偏少，仍需大规模高质量的随机对照临床观察证实本结论。 |
| 关键词: 心肾综合征 温阳利水 炎症因子 Meta分析 |
| DOI：10.3969/j.issn.1674-070X.2020.02.012 |
| Received:September 16, 2019 |
| 基金项目:湖南省教育厅一般项目（18C0366）。 |
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| Clinical Efficacy of Wenyang Lishui Therapy Combined with Western Medicine in the Treatment of Cardiorenal Syndrome and the Effect on Inflammatory Factors:A Meta-Analysis |
| FENG Jun,WANG Weisong,ZENG Fanyu,TAN Cai,LIU Jianhe |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy of Wenyang Lishui therapy combined with western medicine in the treatment of cardiorenal syndrome and the effect on common inflammatory factors by meta-analysis. Methods By computer retrieval, 5 Chinese and English databases (CNKI, Wanfang Data, the Chinese biomedical literature database, PubMed, Web of science) were searched for screening randomized controlled clinical trials (RCTs) on Wenyang Lishui type of traditional Chinese medicine combined with western medicine in the treatment of cardiorenal syndrome, which were published from the establishment of database to July 2019. After screening, 13 studies were eventually included, with a total of 1 268 patients. Revman5.3 software was used for statistical analysis. Results Wenyang Lishui therapy combined with western medicine in the treatment of cardiorenal syndrome was better than western medicine treatment alone in the total effective rate, improving left ventricular ejection fraction, reducing left ventricular end-diastolic diameter, reducing n-terminal brain natriuretic peptide precursor, reducing serum creatinine, urea nitrogen, increasing glomerular filtration rate and improving inflammatory response were all better than that of western medicine alone. Conclusion On the basis of conventional western medicine treatment of cardiovascular and renal syndrome, combined with Wenyang Lishui herbs can significantly improve its efficacy, and its mechanism may be related to reducing its inflammatory response. However, the quality of existing studies is relatively low, and the number of included cases is relatively small. Therefore, large-scale high-quality randomized controlled clinical observation is still needed to confirm this conclusion. |
| Key words: cardiorenal syndrome Wenyang Lishu therapy inflammatory factors Meta-analysis |
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