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文雯,梁慧慧,余格,赵靖,李原华,刘文龙,刘红宇.中药注射剂类过敏反应研究进展[J].湖南中医药大学学报英文版,2020,40(1):117-122.[Click to copy
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| 中药注射剂类过敏反应研究进展 |
| 文雯,梁慧慧,余格,赵靖,李原华,刘文龙,刘红宇 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;中药成药性与制剂制备湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学药学院, 湖南 长沙 410208) |
| 摘要: |
| 中药注射剂（traditional chinese medicine injections，TCMIs）临床疗效确切，但其类过敏反应频发，日益增多的不良反应事件已成为当前中药安全性研究的热点和难点。类过敏反应的发生机制尚未完全明确，其常规评价标准及风险防控措施还存在一定局限性，亟需建立一套能广泛筛查TCMIs类致敏原、明确类致敏发生机制的TCMIs安全性评价方法。本文对近年来有关TCMIs类过敏反应的机制、物质基础以及评价方法的研究进行综述，旨在深入挖掘TCMIs类过敏反应的综合信息，以期为建立TCMIs类过敏反应评价与风险防控新方法、减少TCMIs临床不良反应的发生提供新的思路。 |
| 关键词: 中药注射剂 类过敏反应 不良反应 物质基础 细胞模型 动物模型 |
| DOI：10.3969/j.issn.1674-070X.2020.01.026 |
| Received:September 12, 2019 |
| 基金项目:湖南省教育厅重点研究项目（18A216）；湖南中医药大学研究生创新课题（2018CX52）。 |
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| Advance in Studies on Anaphylactoid Reactions of Traditional Chinese Medicine Injections |
| WEN Wen,LIANG Huihui,YU Ge,ZHAO Jing,LI Yuanhua,LIU Wenlong,LIU Hongyu |
| (First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine, Changsha, Hunan 410208, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Traditional Chinese medicine injections (TCMIs) have definite clinical efficacy, while their anaphylactoid reactions are frequent, and the increasing number of adverse reaction events has become a hot and difficult point in the research of Chinese materia medica safety. The mechanism is not completely clear, and there are still some limitations in conventional evaluation criteria and risk control measures. It is urgent to establish the safety evaluation methods for TCMIs, which can widely screen the allergens and clarify the mechanism of anaphylactoid reactions. In this paper, the research on the mechanism, material basis and evaluation methods of TCMIs anaphylactoid reactions in recent years were reviewed. The purpose is to dig out the comprehensive information related to the reactions, in order to provide the ideas for establishing a new risk control method for anaphylactoid reaction evaluation, so as to reduce the occurrence of clinical adverse reactions of TCMIs. |
| Key words: traditional Chinese medicine injections anaphylactoid reactions adverse reactions material base cell model animal model |
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