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李艳华,唐智军,夏锴,余挽澜,殷延陵,曹卉,王超,彭裕坤,蒋模威.复方鸡子黄油膏对大鼠创面修复中EGFR、FN、TGF-β1表达的影响[J].湖南中医药大学学报英文版,2019,39(12):1449-1452.[Click to copy
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| 复方鸡子黄油膏对大鼠创面修复中EGFR、FN、TGF-β1表达的影响 |
| 李艳华,唐智军,夏锴,余挽澜,殷延陵,曹卉,王超,彭裕坤,蒋模威 |
| (湖南中医药大学附属常德医院, 湖南 常德 415000;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察复方鸡子黄油膏对大鼠创面修复不同时期创面组织中表皮生长因子受体（epithelial growth factor receptor，EGFR）、纤维结合蛋白（fibronectin，FN）含量及转化生长因子β1（transforming growth factor-β1，TGF-β1）表达的影响。方法 选取雌雄各半实验大鼠40只，随机分为空白组、模型组、龙珠软膏组（龙珠组）、复方鸡子黄油膏组（鸡子黄组），除空白组外，每组予以小面积全层皮肤缺损创面造模，造模成功后各组予以相应干预，连续14 d，除空白组随机取背部皮肤组织外，其他3组均分别于第7、14天取创面组织制作切片并同时进行免疫组化法测定EGFR、FN、TGF-β1。结果 治疗后第7、14天鸡子黄组EGFR、FN、TGF-β1含量均高于其他各组（P<0.05）。结论 复方鸡子黄油膏通过提高创面EGFG、FN、TGF-β1的含量促进局部组织再生而起修复作用。 |
| 关键词: 复方鸡子黄油膏 创面损伤修复 表皮生长因子受体 纤维结合蛋白 转化生长因子β1 |
| DOI：10.3969/j.issn.1674-070X.2019.12.006 |
| Received:June 29, 2019 |
| 基金项目:湖南省自然科学基金项目（2015JJ6087）；湖南省中医药管理局项目（201631）。 |
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| Effects of Compound Jizihuang Ointment on Expression of EGFR, FN and TGF-β1 in Excisional Wounded Rats |
| LI Yanhua,TANG Zhijun,XIA Kai,YU Wanlan,YIN Yanling,CAO Hui,WANG Chao,PENG Yukun,JIANG Mowei |
| (Changde Affiliated Hospital to Hunan University of Chinese Medicine, Changde, Hunan 415000, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the effects of Compound Jizihuang Ointment on expression of epidermal growth factor receptor (EGFR), fibronectin (FN) and transforming growth factor-β1 (TGF-β1) in the granulation tissue at different stages of a rat model of excisional wound. Methods A total of 20 male and 20 female experimental rats were selected and randomly divided into a blank group, a model group, a Longzhu Ointment group (Longzhu group), a Compound Jizihuang Ointment (Jizihuang group). Except the blank group, each group was modeled with a small area full-thickness skin defect wound. After successful modeling, each group was intervened for 14 consecutive days accordingly. For the blank group, the back skin tissue was randomly taken. For the other 3 groups, wound tissue was taken for section at 7 days and 14 days and immunohistochemical method was used to determine EGFR, FN and TGF-β1. Results The expression of EGFR, FN and TGF-β1 of the Jizihuang group at 7 days and 14 days were significantly higher than other groups (P<0.05). Conclusion Compound Jizihuang Ointment can repair the wound by increasing the content of epidermal growth factor receptor, fibronectin, and transforming growth factor β1 in the wound surface to promote local tissue regeneration. |
| Key words: Compound Jizihuang Ointment excisional wound healing epidermal growth factor receptor fibronectin transforming growth factor-β1 |
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