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彭西兰,张洁瑜,刘远成,朱竞,吕文辉,刘洋.中药保留灌肠治疗湿热内蕴型溃疡性结肠炎的临床研究[J].湖南中医药大学学报英文版,2019,39(11):1395-1398.[Click to copy
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| 中药保留灌肠治疗湿热内蕴型溃疡性结肠炎的临床研究 |
| 彭西兰,张洁瑜,刘远成,朱竞,吕文辉,刘洋 |
| (合肥市滨湖医院, 安徽 合肥 230031) |
| 摘要: |
| 目的 探讨中药保留灌肠治疗湿热内蕴型溃疡性结肠炎的疗效及对血清中白细胞介素-8（interleukin-8，IL-8）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）表达的影响。方法 选取80例湿热内蕴型溃疡性结肠炎患者，分为观察组（n=40）和对照组（n=40），2组均给予奥沙拉嗪治疗，对照组给予0.5%甲硝唑注射液+锡类散治疗，观察组给予自拟中药方煎剂+锡类散治疗，观察两组治疗前及治疗30 d后的中医症状积分、中医证候疗效、复发率、电子肠镜下黏膜疗效、治疗前及治疗30 d后的病变组织炎症情况。结果 治疗后，两组的中医症状积分显著降低（P<0.05），观察组变化幅度显著大于对照组（P<0.05）；观察组的中医疗效总有效率（90.0%）显著高于对照组（72.5%）（P<0.05）；观察组的电子肠镜黏膜总有效率（92.5%）显著高于对照组（75.0%）（P<0.05），复发率（7.5%）显著低于对照组（25.0%）（P<0.05）；治疗后，两组血清中IL-8及TNF-α浓度显著下降（P<0.05），观察组下降幅度显著大于对照组（P<0.05）。结论 中药保留灌肠治疗湿热内蕴型溃疡性结肠炎疗效显著，可明显改善相关症状，提高观察组黏膜修复疗效，减轻病变组织炎症反应，患者复发率低。 |
| 关键词: 溃疡性结肠炎 湿热内蕴 中药保留灌肠 白细胞介素-8 肿瘤坏死因子-α |
| DOI：10.3969/j.issn.1674-070X.2019.11.023 |
| Received:June 10, 2019 |
| 基金项目:合肥市中医药专项（2100601）。 |
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| Clinical Study on the Treatment of Ulcerative Colitis of Internal Accumulation of Damp-Heat Syndrome with Chinese Herbal Medicine Retention Enema |
| PENG Xilan,ZHANG Jieyu,LIU Yuancheng,ZHU Jing,LYU Wenhui,LIU Yang |
| (Hefei Binhu Hospital, Hefei, Anhui 230031, China) |
| Abstract: |
| Objective To investigate the curative effect of retention enema with Chinese herbal medicine in the treatment of ulcerative colitis (UC) of internal accumulation of damp-heat syndrome and its effects on the expression of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in serum. Methods A total of 80 patients with UC of internal accumulation of damp-heat syndrome were randomly divided into a control group (n=40) and an observation group (n=40). Both groups were treated with olsalazine. The control group was treated with 0.5% metronidazole injection combined with tin-like powder, while the observation group was treated with self-made Chinese herbal medicine decoction combined with tin-like powder. The traditional Chinese medicine (TCM) symptom scores before treatment and after 30 days of treatment, curative effect of TCM syndrome, recurrence rate, curative effect of mucosa under electronic colonoscope, inflammation of diseased tissues before treatment and after 30 days of treatment were observed. Results After treatment, the scores of TCM symptoms in both groups were significantly decreased (P<0.05), and the changes in the observation group were significantly greater than those in the control group (P<0.05). The total TCM effective rate in the observation group (90.0%) was significantly higher than that in the control group (72.5%) (P<0.05). The total effective rate of mucosa under electronic colonoscope in the observation group (92.5%) was significantly higher than that in the control group (75.0%) (P<0.05), and the recurrence rate (7.5%) was significantly lower than that in the control group (25.0%) (P<0.05). After treatment, the concentrations of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in both groups were significantly decreased (P<0.05), and the decrease in the observation group was significantly greater than that in the control group (P<0.05). Conclusion Retention enema with Chinese herbal medicine is significantly effective in the treatment of UC of internal accumulation of damp-heat syndrome. It can significantly relieve related symptoms, improve the effect of mucosal repair, and reduce the inflammation of diseased tissues, with a low recurrence rate. |
| Key words: ulcerative colitis internal accumulation of damp-heat retention enema with Chinese herbal medicine interleukin-8 tumor necrosis factor-α |
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