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王胜,龚毅,袁青青,刘晓龙,钱海兵.苗药小血藤对缺血性脑卒中大鼠的作用研究[J].湖南中医药大学学报英文版,2019,39(11):1336-1339.[Click to copy
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| 苗药小血藤对缺血性脑卒中大鼠的作用研究 |
| 王胜,龚毅,袁青青,刘晓龙,钱海兵 |
| (中国人民解放军联勤保障部队第983医院, 天津 300142;贵州中医药大学, 贵州 贵阳 550002) |
| 摘要: |
| 目的 研究苗药小血藤对缺血性脑卒中大鼠的治疗作用，并初步探讨其可能的作用机制。方法 用改良线栓法制作大鼠大脑中动脉闭塞（middle cerebral artery occlusion，MCAO）模型。将造模成功的大鼠随机分为假手术组、模型组、阳性组、苗药小血藤高、中、低剂量组（3.75、1.875、0.937 5 g/kg），给予相应药物1次/d灌胃给药，连续7 d。TTC染色观察脑梗死面积；试剂盒检测血清超氧化物歧化酶（superoxide dismutase，SOD）、丙二醛（maleic dialdehyde，MDA）含量；HE染色观察脑组织病理改变。结果 与模型组比较，小血藤水煎液各剂量组脑梗死面积明显减少（P<0.05），大鼠脑组织匀浆中所含SOD活性显著提高（P<0.05）；MDA含量显著降低（P<0.05）；HE染色发现，小血藤水煎液各剂量组可一定程度上改善MCAO大鼠海马区病理损伤。结论 小血藤水煎液对MCAO导致的脑缺血大鼠可以减少梗死面积，促进其神经功能恢复，对缺血造成的损伤具有一定的保护作用，其机制可能与小血藤抗氧化应激损伤有关。 |
| 关键词: 小血藤 缺血性脑卒中 超氧化物歧化酶 丙二醛 |
| DOI：10.3969/j.issn.1674-070X.2019.11.009 |
| Received:June 25, 2019 |
| 基金项目:贵州省国内一流建设学科项目（中药学）（GNYL[2017]008号）；贵州省普通高等学校特色重点实验室建设任务（黔教合KY字[2017]006）。 |
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| Study on the Effects of Miao Medicine Schisandra Propinqua on Rats with Ischemic Stroke |
| WANG Sheng,GONG Yi,YUAN Qingqing,LIU Xiaolong,QIAN Haibing |
| (The No. 983 Hospital of The Joint Logistic Guarantee Force of PLA, Tianjin 300142, China;Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550002, China) |
| Abstract: |
| Objective To investigate the therapeutic effect of Miao medicine Schisandra Propinqua on ischemic stroke rats, and to discuss its possible mechanism. Methods The modified thread thrombus method was used sto establish middle cerebral artery occlusion model (MCAO). The successfully modeled rats were randomly divided into a sham operation group, a model group, and a high, middle, low dose of Miao medicine Schisandra Propinqua group (3.75, 1.875, 0.9375 g/kg). The rates were given intragastric administration of drugs once a day, for 7 days. The volume of cerebral infarction was observed by TTC staining. The contents of superoxide dismutase (SOD) and maleic dialdehyde (MDA) in the serum were measured by kit, and the pathological changes of brain tissue were observed by HE staining. Results Compared with the model group, the volume of cerebral infarction in the all dose groups of Schisandra Propinqua decoction was significantly decreased (P<0.05), SOD activity contained in the brain tissue was significantly increased (P<0.05), and content of MDA was significantly decreased (P<0.05). HE staining found that each dose group of Schisandra Propinqua could improve the hippocampal injury of rats after MCAO to some extent. Conclusion The decoction of Schisandra Propinqua can reduce the volume of infarction and promote the recovery of nerve function in rats with cerebral ischemia caused by middle artery occlusion, and has a certain protective effect on the injury caused by ischemia. The mechanism may be related to the antioxidant stress injury of Schisandra Propinqua. |
| Key words: Schisandra Propinqua cerebral arterial thrombosis superoxide dismutase maleic dialdehyde |
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