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李姿蓉,韩远山,王宇红,罗薇絮,凌佳,赵洪庆.从抑郁共病失眠机制探寻抑郁症新药研发的方向[J].湖南中医药大学学报英文版,2019,39(10):1279-1284.[Click to copy
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| This paper
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| 从抑郁共病失眠机制探寻抑郁症新药研发的方向 |
| 李姿蓉,韩远山,王宇红,罗薇絮,凌佳,赵洪庆 |
| (湖南中医药大学科技创新中心, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 抑郁症是一种常见的情感障碍类精神疾病，失眠是包括抑郁障碍在内的诸多精神疾病的独立危险因素，失眠不仅是抑郁的症状之一，抑郁与失眠是一种循环往复持续进展的一种共同疾病状态。本文就近年来抑郁症与失眠发病共同机制作一综述，初步探寻研发抑郁症新药的方向。 |
| 关键词: 抑郁 失眠 发病机制 |
| DOI：10.3969/j.issn.1674-070X.2019.10.024 |
| Received:February 12, 2019 |
| 基金项目:国家自然科学基金面上项目（81573965）；国家重大新药创制（2017ZX09309026）；2019湖南省研究生科研创新项目（CX20190565）；湖南省一流学科资助项目（中医学）基金（2018ZYX50）。 |
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| Exploring the Direction of Research and Development of New Drugs for Depression from the Mechanism of Comorbid Depression and Insomnia |
| LI Zirong,HAN Yuanshan,WANG Yuhong,LUO Weixu,LING Jia,ZHAO Hongqing |
| (Scientific and Technological Innovation Center, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Depression is a common mental disorder of affective disorder. Insomnia is an independent risk factor for many mental illnesses including depressive disorder. Insomnia is only one of the symptoms of depression. Depression and insomnia is a comorbid state moving in circles and developing continuously. The pathological mechanism of depression and insomnia in recent years is reviewed in this paper to preliminarily explore the direction of research and development of new drugs for depression. |
| Key words: depression insomnia pathogenesis |
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