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马慧淼,陈媚,杨嘉欣,邓博,程志强.基于数据挖掘探索中药外用治疗手足综合征的用药规律[J].湖南中医药大学学报英文版,2019,39(9):1120-1124.[Click to copy
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| 基于数据挖掘探索中药外用治疗手足综合征的用药规律 |
| 马慧淼,陈媚,杨嘉欣,邓博,程志强 |
| (北京中医药大学, 北京 100029;中日友好医院中西医结合肿瘤内科, 北京 100029;北京中医药大学, 北京 100029;中日友好医院皮肤科, 北京 100029) |
| 摘要: |
| 目的 整理总结治疗化疗副作用手足综合征中药外用方剂的用药规律，对手足综合征中药辨证进行分析。方法 筛选基于PubMed数据库、万方数据知识服务平台、维普网、中国期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）收录的中药外治法治疗手足综合征的临床研究文献，对符合纳入标准的中药处方进行统计，采用频次分析、关联规则分析等数据挖掘方法进行用药规律分析。结果 共筛选55个外用中药治疗手足综合征的处方，涉及中药105味，总共出现频次497次。频数最高的药物为红花和桂枝（34次）；药物功效使用频率最高的前5类为活血调经药、发散风寒药、清热凉血药、补气药、补血药；关联分析显示：二连规则前3名为：桂枝→白芍，桂枝→鸡血藤，红花→桃仁；三连规则常用的药物组合为当归、黄芪、桂枝，四连规则支持度最高为当归→黄芪+桂枝+红花。结论 本病病机为气血虚弱、营卫失和，日久可发展为淤血痹阻、热毒内蕴，外治法中药多用活血通络、温阳解表、清热凉血兼补益气血为主。 |
| 关键词: 数据挖掘 手足综合征 用药规律 关联规则 |
| DOI：10.3969/j.issn.1674-070X.2019.09.015 |
| Received:April 03, 2019 |
| 基金项目:国家自然科学基金项目（81603462）。 |
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| Data Mining-based Exploration on Medication Rules of External Treatment of Chinese Materia Medica in Hand-foot Syndrome |
| MA Huimiao,CHEN Mei,YANG Jiaxin,DENG Bo,CHENG Zhiqiang |
| (Beijing University of Chinese Medicine, Beijing 100029, China;Oncology Department of Integrated Traditional Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China;Beijing University of Chinese Medicine, Beijing 100029, China;Dermatology Department, China-Japan Friendship Hospital, Beijing 100029, China) |
| Abstract: |
| Objective To summarize medication rules of prescriptions of Chinese materia medica (CMM) in external treatment of a side effect induced by chemotherapy-hand-foot syndrome (HFS), and to analyze CMM syndrome differentiation in HFS. Methods Clinical research literatures on CMM external treatment in HFS included in PubMed database, Wanfang database, VIP database, China National Knowledge Infrastructure (CNKI) database, and China Biology Medicine disc (CBM) were screened. CMM prescriptions meeting inclusion criteria were performed statistical analysis. Methods of data mining such as frequency analysis and association rule analysis were used to analyze the medication rules. Results A total of 55 CMM prescriptions in the external treatment of HFS were included in this study, involving 105 kinds of CMM, with a total frequency of 497 times. Among the CMM, Flos Carthami and Ramulus Cinnamomi were used most frequently (34 times); The top 5 frequently used efficacy of CMM were the CMM with effects of promoting blood circulation and regulating menstruation, expelling wind-cold, clearing heat and cooling blood, invigorating Qi and invigorating blood. The top 3 couplet CMM according to the association rule analysis were Ramulus Cinnamomi-Radix Paeoniae Alba, Ramulus Cinnamomi-Caulis Spatholobi, and Flos Carthami-Semen Persicae; the commonly used triplet CMM according to the association rules was Radix Angelicae Sinensis-Radix Astragali seu Hedysari-Ramulus Cinnamomi; the top 1 quadruple CMM according to the association rules was Radix Angelicae Sinensis-Radix Astragali seu Hedysari-Ramulus Cinnamomi-Flos Carthami. Conclusion The pathogenesis of HFS is Qi-blood deficiency and disharmony between nutrient Qi and defensive Qi. Static blood blockage and internal amassment of heat-toxicity can be formed over the time. The CMM external treatment is mainly promoting blood circulation and dredging channels, warming Yang and relieving superficies, clearing heat and cooling blood, as well as invigorating Qi and blood. |
| Key words: data mining hand-foot syndrome medication rules association rules |
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