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赵志成,史佩玉,邓洁宜,邢万里,王颖.基于网络药理学探讨当归芍药散治疗慢性盆腔炎作用机制[J].湖南中医药大学学报英文版,2019,39(9):1108-1113.[Click to copy
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| 基于网络药理学探讨当归芍药散治疗慢性盆腔炎作用机制 |
| 赵志成,史佩玉,邓洁宜,邢万里,王颖 |
| (黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040;广州中医药大学第一临床医学院, 广东 广州 510405;广州中医药大学第二临床医学院, 广东 广州 510405) |
| 摘要: |
| 目的 基于网络药理学探讨当归芍药散治疗慢性盆腔炎的作用机制。方法 利用TCMSP数据库筛选出当归芍药散活性成分及其相关靶标基因；使用Genecards数据库筛选慢性盆腔炎靶标基因；借助STRING在线数据库获取靶标基因相互作用关系；采用David数据库进行GO生物学过程分析和KEGG通路功能富集分析；利用cytoscape软件构建当归芍药散治疗慢性盆腔炎“活性成分-作用靶标-通路”网络。结果 当归芍药散的核心活性成分有山柰酚、β-谷甾醇等，核心作用靶标有PTGS2、TNF、JUN等；GO生物学过程分析结果表明当归芍药散活性成分的基因功能主要表现在药物反应、RNA聚合酶Ⅱ启动子转录的正调节、凋亡过程的负调节、信号转导等生物学过程； KEGG结果表明当归芍药散主要作用与TNF、Toll样受体等信号通路有关。结论 当归芍药散活性成分山柰酚、β-谷甾醇等可能通过TNF、Toll样受体等信号通路作用于PTGS2、TNF-α、JUN、IL-6等关键靶标基因进而发挥其临床功效，达到治疗慢性盆腔炎等疾病的目的。 |
| 关键词: 慢性盆腔炎 当归芍药散 网络药理学 通路 机制 |
| DOI：10.3969/j.issn.1674-070X.2019.09.013 |
| Received:June 10, 2019 |
| 基金项目:国家自然科学基金资助项目（81703724）。 |
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| Exploration on Mechanism of Danggui Shaoyao Powder in Chronic Pelvic Inflammatory Based on Network Pharmacology |
| ZHAO Zhicheng,SHI Peiyu,DENG Jieyi,XING Wanli,WANG Ying |
| (The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China;The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China) |
| Abstract: |
| Objective To explore the mechanism of Danggui Shaoyao Powder in chronic pelvic inflammatory based on network pharmacology. Methods TCMSP database was used for screening effective components of Danggui Shaoyao Powder and related target genes; target genes for chronic pelvic inflammatory were screened by using Genecards database; interaction relationship of target genes was acquired by STRING online database; David database was used for GO biological progress analysis and pathway enrichment analysis of KEGG; active component-target-pathway network of Danggui Shaoyao Powder in chronic pelvic inflammatory was structured by Cytoscape software. Results The core active components of Danggui Shaoyao Powder were kaempferol, β-sitosterol, etc. and the core targets were PTGS2, TNF, JUN, etc. GO biological progress analysis showed that the gene functions of active components of Danggui Shaoyao Powder mainly manifested in biological progresses like drug reaction, positive regulation in transcription of RNA polymerase Ⅱ promoter, negative regulation in apoptotic process, signal transduction and so on; KEGG results showed that the main function of Danggui Shaoyao Powder was related to signaling pathways like TNF signaling pathway, Toll-like receptor signaling pathway and so on. Conclusion Kaempferol, β-sitosterol and other active components of Danggui Shaoyao Powder may act on PTGS2, TNF-α, JUN, IL-6 and other key target genes through signaling pathways like TNF signaling pathway and Toll-like receptor signaling pathway, thus exerting its clinical efficacy, so as to achieve the goal of treating chronic pelvic inflammation and other diseases. |
| Key words: chronic pelvic inflammatory Danggui Shaoyao Powder network pharmacology pathway mechanism |
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