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彭佳,谭波宇,宁宁.注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性系统评价[J].湖南中医药大学学报英文版,2019,39(8):1035-1039.[Click to copy
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| 注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性系统评价 |
| 彭佳,谭波宇,宁宁 |
| (湖南省人民医院药学部, 湖南 长沙 410005;湖南师范大学医学院, 湖南 长沙 410006) |
| 摘要: |
| 目的 系统评价注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的有效性和安全性，为临床应用提供循证医学证据。方法 计算机检索CBM、CNKI、VIP、WanFang Data等数据库，纳入注射用炎琥宁与α-干扰素治疗小儿上呼吸道感染的随机对照试验（RCT）或半随机对照试验（qRCT），检索时间为建库至今，对符合纳入标准的研究进行质量评价，并使用Rev Man 5.3软件进行Meta分析。结果 共纳入10项研究，合计1104例患儿。Meta分析结果显示，注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染可以显著提高患儿的总有效率（OR=4.99，95%CI：3.22~7.74，P<0.01），缩短退热时间（MD=-1.39，95%CI：-1.87~-0.92，P<0.01）、咳嗽消失时间（MD=-1.54，95%CI：-2.25~-0.83，P<0.01）、鼻塞流涕消失时间（MD=-1.65，95%CI：-2.35~-0.95，P<0.01）。结论 注射用炎琥宁与α-干扰素治疗小儿呼吸系统感染疗效较好，可明显缩短患儿退热时间、咳嗽消失时间、鼻塞流涕消失时间。 |
| 关键词: 炎琥宁 α-干扰素 小儿呼吸系统感染 系统评价 |
| DOI：10.3969/j.issn.1674-070X.2019.08.023 |
| Received:March 02, 2018 |
| 基金项目:湖南省中医药管理局（2016149）。 |
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| Efficacy and Safety of Yanhuning Combined with Interferon-α in the Treatment of Children with Respiratory Infection:A Systematic Review |
| PENG Jia,TAN Boyu,NING Ning |
| (Department of Pharmacy, People's Hospital of Hunan, Changsha, Hunan 410005, China;Medical College, Hunan Normal University, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To systematically review the effects and safety of Yanhuning and α-interferon in the treatment of respiratory infection in children, and provide evidence-based basis for clinical application. Methods The randomized controlled trails (RCTs) or semi-randomized controlled trials (qRCTs) on Yanhuning and α-interferon in the treatment of respiratory infection in children were searched in CBM, CNKI, VIP, WanFang Data from the date of their establishment to October 2017. According to the inclusion criteria, the quality for the requirements of RCT and meta-analysis were performed with Rev-Man 5.3 software. Results Totally 10 studies were enrolled,involving 1104 patients. Results of meta-analysis showedthe Yanhuning and α-interferon for injection in the treatment of children respiratory system infections can significantly improve the clinical total effective rate(OR=4.99, 95%CI:3.22-7.74, P<0.01), shorten fever duration (MD=-1.39, 95%CI:-1.87——0.92, P<0.01), cough duration (MD=-1.54, 95%CI:-2.25--0.83, P<0.01), runny nose duration(MD=-1.65, 95%CI:-2.35--0.95, P<0.01). Conclusion The Yanhuning and α-interferon for injection can improve the clinical eficacy in the treatment of children respiratory system infections,and significantlyshorten fever duration, cough duration and runny nose duration. |
| Key words: Yanhuning α-interferon children respiratory system infections systematic review |
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