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黄姗姗,刘慧萍,张韫玉,陈镇,张楚洁,付慧兰,肖小芹.卵巢颗粒细胞自噬与PI3K/AKT/FOXO3a信号通路的相关性[J].湖南中医药大学学报英文版,2019,39(6):775-780.[Click to copy
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| 卵巢颗粒细胞自噬与PI3K/AKT/FOXO3a信号通路的相关性 |
| 黄姗姗,刘慧萍,张韫玉,陈镇,张楚洁,付慧兰,肖小芹 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 细胞自噬是哺乳动物细胞物质代谢的一个重要机制，与细胞凋亡共同参与卵巢卵泡的发育和闭锁，并发挥重要的作用。近年研究发现，磷脂酰肌醇3-激酶/蛋白激酶B（phosphatidylinositol 3-kinase/protein kinase B，PI3K/AKT）信号通路参与卵巢疾病的发生。PI3K和AKT的过度激活可使原始卵泡过早发育以及卵泡过快凋亡，卵巢颗粒细胞作为卵泡发育重要的支持细胞，其功能的减退或凋亡很可能引发一系列女性内分泌方面的疾病。FOXO3a转录因子是PI3K/AKT信号通路下游的重要靶蛋白之一，参与抗增殖和凋亡。本文就关于卵巢颗粒细胞自噬与PI3K/AKT/FOXO3a信号通路的相关进展加以综述。 |
| 关键词: 卵巢 卵泡 颗粒细胞 自噬 PI3K/AKT/FOXO3a信号通路 |
| DOI：10.3969/j.issn.1674-070X.2019.06.023 |
| Received:September 17, 2018 |
| 基金项目:国家自然科学基金项目（81303123）；湖南省自然科学基金面上项目（2018JJ2299）；湖南省教育厅创新平台项目（18K069）；湖南省中医药科研计划项目重点项目（201801，201815，201495）；湖南省教育厅科研项目（17C1219）；国家级大学生研究性学习与创新性实验计划项目（201810541001）；湖南省大学生研究性学习与创新性实验计划项目（2016-281，2018-400）；湖南中医药大学大学生研究性学习与创新性实验计划项目（2017-2，2016-6）。 |
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| Correlation Between Ovarian Granulosa Cell Autophagy and PI3K/AKT/FOXO3a Signaling Pathway |
| HUANG Shanshan,LIU Huiping,ZHANG Yunyu,CHEN Zhen,ZHANG Chujie,FU Huilan,XIAO Xiaoqin |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Autophagy is an important mechanism of material metabolism in mammalian cells. Together with apoptosis, it plays an important role in the development and atresia of ovarian follicles. In recent years, it has been found that phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway is involved in ovarian diseases. Excessive activation of PI3K and AKT can lead to premature development of primordial follicles and excessive apoptosis of follicles. As important supporting cells of follicular development, the functional decline or apoptosis of ovarian granulosa cells may lead to a series of female endocrine diseases. As one of the most important target proteins in the downstream of PI3K/AKT signaling pathway, FOXO3a transcription factor is involved in anti-proliferation and apoptosis. This paper reviewed the progress in the correlation between ovarian granulosa cells autophagy and PI3K/AKT/FOXO3a signaling pathway. |
| Key words: ovary follicle granulosa cells autophagy PI3K/AKT/FOXO3a signaling pathway |
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