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龙远雄,孙克伟,雍苏南.基于因子分析和关联规则挖掘乙型肝炎肝硬化中医用药配伍规律[J].湖南中医药大学学报英文版,2019,39(6):767-770.[Click to copy
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| 基于因子分析和关联规则挖掘乙型肝炎肝硬化中医用药配伍规律 |
| 龙远雄,孙克伟,雍苏南 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 分析中医药治疗乙型肝炎肝硬化用药配伍规律，为临床治疗提供用药指导。方法 收集本院2016年6月-2017年12月符合入选条件的165例乙型肝炎肝硬化患者的临床资料，运用因子分析与关联规则等方法对其用药规律进行挖掘。结果 纳入处方总数共206个，共198味中药，使用频次排名前10的中药依次为：白术、茯苓、泽泻、茵陈蒿、甘草、柴胡、黄芪、丹参、鳖甲、白芍；常用的2味药物组合模式38组，3味强关联药物组合5个；因子分析法将药物按其功效进行归类，主要分为6大类。结论 本院乙型肝炎肝硬化体现的主要治法：清热利湿，活血祛瘀、通络软坚，疏肝健脾，健脾利湿，补益肝肾，温补脾肾，该研究可为乙型肝炎肝硬化的中医药治疗提供一定参考。 |
| 关键词: 乙型肝炎 肝硬化 中医药治疗 配伍规律 |
| DOI：10.3969/j.issn.1674-070X.2019.06.021 |
| Received:March 10, 2019 |
| 基金项目:国家自然科学基金青年科学基金（81804077）；"中医药防治重症肝炎临床服务能力建设"开放基金（ZZGY06）；国家中医药管理局中医药部门公共卫生专项"中医药防治重大疑难疾病服务能力建设"（2100409）；湖南省自然科学基金（青年基金项目）（2019JJ50468）；湖南中医药大学中医学国内一流建设学科。 |
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| Exploration on the Compatibility Law of Traditional Chinese Medicine for Hepatitis B Cirrhosis Based on Factor Analysis and Association Rules |
| LONG Yuanxiong,SUN Kewei,YONG Sunan |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To analyze the compatibility law of traditional Chinese medicine (TCM) in the treatment of hepatitis B cirrhosis, and to provide medication guidance for clinical treatment. Methods The clinical data of 165 patients with hepatitis B cirrhosis in our hospital from June 2016 to December 2017 were collected, and the compatibility law were explored by methods like factor analysis and association rules. Result There were 206 prescriptions included, with a total of 198 kinds of TCM. The top 10 kinds of TCM used were:Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis, Herba Artemisiae Scopariae, Radix et Rhizoma Glycyrrhizae, Radix Bupleuri, Radix Astragali, Radix et Rhizoma Salviae Miltiorrhizae, Carapax Trionycis and Radix Paeoniae Alba. There were 38 commonly used couplet medicines and 5 strongly associated combinations of 3 kinds of TCM. According to the functions, the TCM was classified into 6 major categories by factor analysis. Conclusion The main treatment methods of hepatitis B cirrhosis in our hospital are:clearing heat and draining dampness, invigorating blood and dissolving stasis, unblocking the collaterals and softening hard masses, soothing the liver and strengthening the spleen, strengthening the spleen and draining dampness, replenishing and boosting the liver and kidney, as well as warming and replenishing the spleen and kidney. This study can provide certain references for TCM therapy in hepatitis B cirrhosis. |
| Key words: hepatitis B liver cirrhosis TCM therapy compatibility law |
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