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李小鹏,席建元,谢汶芳,彭丹,冯瑞瑶.乌紫解毒颗粒联合卡泊三醇倍他米松软膏治疗结节性痒疹的临床疗效及对TNF-α表达的影响[J].湖南中医药大学学报英文版,2019,39(6):750-753.[Click to copy
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| 乌紫解毒颗粒联合卡泊三醇倍他米松软膏治疗结节性痒疹的临床疗效及对TNF-α表达的影响 |
| 李小鹏,席建元,谢汶芳,彭丹,冯瑞瑶 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察中药乌紫解毒颗粒联合卡泊三醇倍他米松软膏治疗结节性痒疹的临床疗效和安全性及对血清中肿瘤坏死因子-α（tumor necrosis factor-alpha，TNF-α）表达的影响。方法 将65例结节性痒疹患者随机分为对照组32例与治疗组33例，对照组予以卡泊三醇倍他米松软膏外用，治疗组在对照组的基础上加用中药乌紫解毒颗粒口服，治疗4周后对两组的临床疗效进行比较，并检测两组患者治疗前后血清TNF-α的表达水平。结果 对照组总有效率62.5%，治疗组总有效率84.8%，两组临床疗效比较差异具有统计学意义（P<0.05）；治疗后治疗组的皮损积分、瘙痒程度均低于对照组（P<0.05）；两组患者血清TNF-α的表达水平较正常组（健康体检者）明显升高（P<0.05），治疗组治疗后TNF-α水平较治疗前明显降低（P<0.05），且低于对照组（P<0.05）；两组患者均未见明显不良反应发生。结论 中药乌紫解毒颗粒联合卡泊三醇倍他米松软膏治疗结节性痒疹临床疗效确切，安全可靠，且能降低血清TNF-a的表达水平。 |
| 关键词: 结节性痒疹 乌紫解毒颗粒 卡泊三醇倍他米松软膏 肿瘤坏死因子-α 中医药疗法 |
| DOI：10.3969/j.issn.1674-070X.2019.06.017 |
| Received:October 05, 2018 |
| 基金项目: |
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| Clinical Efficacy of Wuzi Jiedu Granules Combined With Calcipotriol Betamethasone Ointment in Treating Prurigo Nodularis and Its Effects on TNF-α Expression |
| LI Xiaopeng,XI Jianyuan,XIE Wenfang,PENG Dan,FENG Ruiyao |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the clinical efficacy and safety of Wuzi Jiedu Granules, combined with calcipotriol betamethasone ointment in the treatment of prurigo nodularis and its effects on TNF-α expression in serum. Methods A total of 65 patients with prurigo nodularis were divided into control group (n=32) and treatment group (n=33) randomly. The control group was given calcipotriol betamethasone ointment externally, and the treatment group was given the Wuzi Jiedu Granules orally on the basis of the treatment in the control group. After 4 weeks of treatment, the clinical efficacy of the 2 groups were compared, and the expression levels of serum TNF-α in the 2 groups before and after treatment were detected. Results After the treatment, the total effective rate of the control group was 62.50%, and that of the treatment group was 84.84%, with statistically significant difference (P<0.05). After the treatment, the skin lesion score and degree of pruritus in the treatment group were lower than those in the control group (P<0.05). The expression levels of serum TNF-α of the patients were significantly higher than that of the normal group (P<0.05). And after the treatment, the TNF-α level in the treatment group was significantly lower than that before the treatment (P<0.05) and that in the control group (P<0.05). No obvious adverse reactions occurred in both groups. Conclusion Wuzi Jiedu Granules combined with calcipotriol betamethasone ointment for the treatment of nodular pruritus is effective, safe and reliable, and can reduce the expression level of TNF-α in serum. |
| Key words: prurigo nodularis Wuzi Jiedu Granules calcipotriol betamethasone ointment TNF-α TCM therapy |
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