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蒋云霞,陈文辉,李双蕾,覃俏娜,陈薇宇.益气养阴清热方对KKAy小鼠GLP-2、IFN-γ、NF-κB的影响[J].湖南中医药大学学报英文版,2019,39(6):704-707.[Click to copy
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| 益气养阴清热方对KKAy小鼠GLP-2、IFN-γ、NF-κB的影响 |
| 蒋云霞,陈文辉,李双蕾,覃俏娜,陈薇宇 |
| (广西中医药大学第一附属医院内分泌科, 广西 南宁 530023;广西中医药大学, 广西 南宁 530001) |
| 摘要: |
| 目的 探讨益气养阴清热方对自发性2型糖尿病（KKAy）小鼠胰高血糖素样肽2（glucagon-like peptide 2，GLP-2）、γ干扰素（interferon gamma，IFN-γ）、核因子κB（nuclear factor kappa beta，NF-κB）的影响。方法 取雄性SPF级KKAy小鼠50只，随机分为模型组，二甲双胍组，益气养阴清热方高、中、低剂量组，每组各10只；另取10只C57BL/6J小鼠作为正常组。各组予以相应干预。干预8周后检测各组小鼠GLP-2、IFN-γ、NF-κB水平。结果 与正常组比较，模型组小鼠IFN-γ、NF-κB明显升高（P<0.01），GLP-2水平明显降低（P<0.01）。益气养阴清热方高、中、低剂量组均可降低KKAy小鼠IFN-γ水平（P<0.05）；益气养阴清热方高剂量组可降低小鼠NF-κB水平（P<0.05）；益气养阴清热方高、中、低剂量组均可升高小鼠GLP-2水平（P<0.05）。结论 益气养阴清热方能改善糖尿病小鼠血糖、胰岛素抵抗，其作用可能与提高GLP-2水平、降低炎症反应相关。 |
| 关键词: 糖尿病 益气养阴清热 胰高血糖素样肽2 γ干扰素 核因子κB |
| DOI：10.3969/j.issn.1674-070X.2019.06.006 |
| Received:July 16, 2018 |
| 基金项目:广西自然科学基金项目（2015GXNSFAA139119）；广西名老中医民族医传承工作室建设项目（桂卫中[2014]9号文件）。 |
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| Effects of Yiqi Yangyin Qingre Formula on GLP-2, IFN-γ and NF-κB in KKAy Mice |
| JIANG Yunxia,CHEN Wenhui,LI Shuanglei,QIN Qiaona,CHEN Weiyu |
| (Endocrine Department, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China;Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China) |
| Abstract: |
| Objective To investigate the effects of Yiqi Yangyin Qingre Formula on glucagon-like peptide 2 (GLP-2), interferon-gamma (IFN-γ) and nuclear factor kappa B (NF-κB) in spontaneous type 2 diabetes (KKAy) mice. Methods A total of 50 male SPF KKAy mice were selected. They were randomly divided into a model group, a metformin group, as well as high, medium and low dose groups of Yiqi Yangyin Qingre Formula, with 10 mice in each group. And 10 C57BL/6J mice were taken as the normal group. Each group was given corresponding intervention. After 8 weeks of intervention, the levels of GLP-2, IFN-γ and NF-κB of mice were measured. Result Compared with the normal group, the levels of IFN-γ and NF-κB in the model group were increased significantly (P<0.01), and the GLP-2 level was decreased significantly (P<0.01). The IFN-γ level of KKAy mice could be decreased in the high, medium and low dose groups of Yiqi Yangyin Qingre Formula (P<0.05). The NF-κB level of mice could be decreased in the high dose group of Yiqi Yangyin Qingre Formula (P<0.05). And the GLP-2 level of mice could be increased in the high, medium and low dose groups of Yiqi Yangyin Qingre Formula (P<0.05). Conclusion Yiqi Yangyin Qingre Formula can reduce blood glucose and insulin resistance in diabetic mice, and its effects may be related to the increase of GLP-2 level and the reduction of inflammatory reaction. |
| Key words: diabetes mellitus Yiqi Yangyin Qingre glucagon-like peptide 2 interferon-gamma nuclear factor-kappa B |
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