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刘鹏,桂壮,邵治国.不同剂量大黄附子细辛汤对慢性肾功能衰竭脾肾阳虚证患者肾功能、CRP、IL-6及TNF-a的影响[J].湖南中医药大学学报英文版,2019,39(5):640-643.[Click to copy
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| 不同剂量大黄附子细辛汤对慢性肾功能衰竭脾肾阳虚证患者肾功能、CRP、IL-6及TNF-a的影响 |
| 刘鹏,桂壮,邵治国 |
| (湖北省荆州市中医医院, 湖北 荆州 434000) |
| 摘要: |
| 目的 探讨不同剂量大黄附子细辛汤对慢性肾衰竭脾肾阳虚证患者炎症因子及临床疗效的观察。方法 120例确诊的慢性肾功能衰竭脾肾阳虚证患者随机分为治疗组和对照组各60例，两组在常规治疗基础之上，对照组给予小剂量大黄附子细辛汤，治疗组给予大剂量大黄附子细辛汤，观察两组患者治疗前后尿素氮（BUN）、血肌酐（Scr）、血清胱抑素C（CysC）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-a （TNF-a）水平、药物不良反应及临床疗效。结果 两组患者血清BUN、Scr、CysC、IL-6、TNF-a较治疗前均明显降低，治疗组下降幅度更为显著（P<0.05），治疗组治疗后中医证候积分及综合疗效均优于对照组（P<0.05），治疗后2组安全性比较无显著差异（P>0.05）。结论 大剂量大黄附子细辛汤对慢性肾功能衰竭脾肾阳虚证患者中有助于改善肾功能，降低炎症因子水平，可能与降低血清炎性因子IL-6、TNF-a值，发挥抗炎及促进肾代谢作用有关。 |
| 关键词: 慢性肾功能衰竭 脾肾阳虚证 大黄附子细辛汤 炎症因子 临床疗效 |
| DOI：10.3969/j.issn.1674-070X.2019.05.018 |
| Received:April 10, 2018 |
| 基金项目:荆州市科技局医疗卫生科技计划项目（[2016]26-65） |
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| Effects of Different Dosage of Dahuang Fuzi Xixin Decoction on Renal Function, CRP, IL-6 and TNF-α in Patients with Chronic Renal Failure with Spleen-Kidney Yang Deficiency Syndrome |
| LIU Peng,GUI Zhuang,SHAO Zhiguo |
| (Hubei Jingzhou City Hospital of Traditional Chinese Medicine, Jingzhou, Hubei 434000, China) |
| Abstract: |
| Objective To explore the effects of different doses of Dahuang Fuzi Xixin Decoction on inflammatory factors and clinical efficacy in patients with chronic renal failure with syndrome of spleen and kidney Yang deficiency. Methods A total of 120 patients with chronic renal failure diagnosed with spleen and kidney Yang deficiency syndrome were randomly divided into a treatment group and a control group, with 60 cases in each group. The 2 groups were given conventional treatment. The control group was given a small dose of Dahuang Fuzi Xixin Decoction, and the treatment group was given large dose. The levels of urea nitrogen (BUN), serum creatinine (Scr), serum cystatin C (CysC), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) were observed before and after treatment, and the adverse drug reactions and clinical effects were also observed before and after treatment. Results The serum levels of BUN, Scr, CysC, IL-6 and TNF-α in the 2 groups were significantly lower than those before treatment, and the decrease in the treatment group was more significant (P<0.05). The TCM syndromes scores and comprehensive efficacy in the treatment group were better than those in the control group after treatment in the treatment group (P<0.05), and there was no significant difference in the safety between the 2 groups (P>0.05). Conclusion Large-dose of Dahuang Fuzi Xixin Decoction can improve renal function and reduce inflammatory factors in patients with chronic renal failure and spleen and kidney Yang deficiency syndrome, which may be related with reducing serum inflammatory factors IL-6 and TNF-α, exerting anti-inflammatory effects, and promoting kidney metabolism. |
| Key words: chronic renal failure spleen and kidney Yang deficiency syndrome Dahuang Fuzi Xixin Decoction inflammatory factor clinical effect |
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