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焦国平,焦计凯.活血消肿散结汤联合左甲腺素钠片治疗结节性甲状腺肿的疗效观察[J].湖南中医药大学学报英文版,2019,39(2):270-273.[Click to copy
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| 活血消肿散结汤联合左甲腺素钠片治疗结节性甲状腺肿的疗效观察 |
| 焦国平,焦计凯 |
| (冀中能源井矿总医院, 河北 石家庄 050051) |
| 摘要: |
| 目的 观察经验方活血消肿散结汤联合左甲腺素钠片治疗结节性甲状腺肿的临床疗效。方法 选取2017年12月至2018年10月收治的104例结节性甲状腺肿患者，按照随机数字表法分为观察组和对照组，每组52例。对照组给予单纯的左甲腺素钠片治疗，观察组在对照组的基础上加用院内经验方活血消肿散结汤治疗，均治疗2个月。观察治疗前后两组患者的甲状腺功能[即甲状腺激素：游离三碘甲状腺原氨酸（free triiodothyronine，FT3）、游离甲状腺素（free thyroxine，FT4）、促甲状腺激素（thyroid stimulating hormone，TSH）的水平]、结节大小、结节个数和中医症状评分，比较两组患者治疗后临床疗效。结果（1）观察组患者的总有效率为90.38%，明显高于对照组的73.08%（P<0.05）；（2）治疗后，两组患者的结节个数和结节直径较治疗前比较，均有所减少（P<0.05），且观察组的结节个数和结节直径较对照组减少更明显（P<0.05）；（3）两组患者治疗前后FT3、FT3水平比较及观察组治疗前后TSH水平比较，差异均无统计学意义（P>0.05），但对照组治疗后TSH水平较治疗前降低，且低于观察组（P<0.05）；（4）治疗后，两组患者中医症状评分均较治疗前下降，且观察组低于对照组（P<0.05）。结论 采用活血消肿散结汤联合左甲腺素钠片治疗结节性甲状腺肿临床效果显著，能够缓解症状及体征，具有一定的安全性，且优于单纯应用左甲腺素钠片治疗。 |
| 关键词: 结节性甲状腺肿 活血消肿散结汤 左甲腺素钠片 甲状腺功能 中医症状评分 |
| DOI：10.3969/j.issn.1674-070X.2019.02.028 |
| Received:October 09, 2018 |
| 基金项目:河北省卫计委课题基金项目（20181110） |
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| Therapeutic Effect of Huoxue Xiaozhong Sanjie Decoction Combined with Levothyroxine Sodium Tablets in Treatment of Nodular Goiter |
| JIAO Guoping,JIAO Jikai |
| (Jizhong Energy Mine General Hospital, Shijiazhuang, Hebei 050051, China) |
| Abstract: |
| Objective To observe the therapeutic effect of Huoxue Xiaozhong Sanjie Decoction combined with levothyroxine sodium tablets in the treatment of nodular goiter. Methods A total of 104 patients with nodular goiter admitted from December 2017 to October 2018 were divided into observation group and control group using a random number table, with 52 cases in each group. The control group was treated with levothyroxine sodium tablets alone, while the observation group was treated with Huoxue Xiaozhong Sanjie Decoction (experienced prescription in our hospital) in addition to the treatment for the control group, both for 2 months. The thyroid function [thyroid hormones: free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH)], nodule size, nodule number, and traditional Chinese medicine (TCM) symptom scores of the two groups were evaluated before and after treatment, and the treatment outcome was compared between the two groups. Results (1) The overall response rate of the observation group was 90.38%, which was significantly higher than that of the control group (73.08%) (P<0.05). (2) After treatment, both groups had significantly decreased number and diameter of nodules (P<0.05), and the observation group had significantly greater decreases in the number and diameter of nodules than the control group (P<0.05). (3) After treatment,either group showed no significant changes in FT3 and FT4 levels, and the observation group showed no significant change in TSH level (P>0.05); however, the control group showed a significant reduction in TSH level after treatment, and it had a significantly lower TSH level than the observation group (P<0.05). (4) Both groups had decreased TCM symptom scores after treatment, which were significantly lower in the observation group than in the control group (P<0.05). Conclusion Huoxue Xiaozhong Sanjie Decoction combined with levothyroxine sodium tablets has a good clinical effect in the treatment of nodular goiter, can alleviate symptoms and signs, and has good safety. It has a superior therapeutic effect to levothyroxine sodium tablets alone, and holds promise for clinical application. |
| Key words: nodular goiter Huoxue Xiaozhong Sanjie Decoction levothyroxine sodium tablet thyroid function traditional Chinese medicine symptom score |
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