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钟新林,蔡江龙,杨立芳,邓美容.健脾生血汤治疗气不摄血型慢性特发性血小板减少性紫癜的临床研究[J].湖南中医药大学学报英文版,2019,39(1):99-103.[Click to copy
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| 健脾生血汤治疗气不摄血型慢性特发性血小板减少性紫癜的临床研究 |
| 钟新林,蔡江龙,杨立芳,邓美容 |
| (衡阳市中医医院, 湖南 衡阳 421001;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察健脾生血汤治疗气不摄血型慢性特发性血小板减少性紫癜（idiopathic thrombocytopenic purpura，ITP）的临床疗效。方法 将符合标准的100例患者随机分为对照组和治疗组，每组50例，两组分别采用激素强的松治疗和健脾生血汤合激素强的松治疗，3个月为1疗程，连用2个疗程。比较治疗前后两组血小板计数、血小板治疗疗效、中医症状积分、中医证候疗效及副反应情况。结果 血小板计数比较：两组治疗后血小板计数均有所上升（P<0.05），治疗组血小板计数上升幅度高于对照组（P<0.05）；血小板治疗疗效比较：对照组总有效率为82.0%，治疗组为90.0%，两组比较差异有统计学意义（P<0.05）；中医症状积分比较：两组治疗后中医症状积分均有所下降（P<0.05），治疗后对照组中医症状积分减少幅度小于治疗组（P<0.05）；中医证候疗效比较：对照组总有效率为82.0%，治疗组为92.0%，两组比较差异有统计学意义（P<0.05）；副反应比较：对照组副反应发生率为100.0%，治疗组为54.0%，两组比较差异有统计学意义（P<0.05）。结论 健脾生血汤能改善气不摄血型慢性ITP患者的中医证候，有效增加血小板计数，改善或消除激素副作用，有推广应用价值。 |
| 关键词: 特发性血小板减少性紫癜 气不摄血 健脾生血汤 |
| DOI：10.3969/j.issn.1674-070X.2019.01.023 |
| Received:September 11, 2018 |
| 基金项目:湖南省中医药科研计划项目（2015163）。 |
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| Clinical Efficacy of Jianpi Shengxue Decoction in Treatment of Chronic Idiopathic Thrombocytopenic Purpura with Qi Failing to Control Blood |
| ZHONG Xinlin,CAI Jianglong,YANG Lifang,DENG Meirong |
| (Hengyang Hospital of Traditional Chinese Medicine, Hengyang, Hunan 421001, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Jianpi Shengxue Decoction in the treatment of chronic idiopathic thrombocytopenic purpura (ITP) with Qi failing to control blood.Methods A total of 100 patients with chronic ITP with Qi failing to control blood were equally and randomly divided into control group and treatment group. The control group was given the glucocorticoid prednisone, while the treatment group was given Jianpi Shengxue Decoction combined with prednisone. Both groups were given two courses of treatment (3 months for a course). The changes in platelet count, response in platelet, traditional Chinese medicine (TCM) symptom score, response in TCM syndrome, and side effects after treatment were compared between the two groups.Results Comparison of platelet count:after treatment, both groups showed a significant increase in platelet count (P<0.05), and the treatment group had a significantly greater increase in platelet count compared with the control group (P<0.05); comparison of response in platelet:there was a significant difference in overall response rate between the control group and the treatment group (82.0% vs 90.0%, P<0.05); comparison of TCM symptom score:after treatment, both groups showed a significant decrease in TCM symptom score (P<0.05), and the control group had a significantly less decrease in TCM symptom score compared with the treatment group (P<0.05); comparison of response in TCM syndrome:there was a significant difference in overall response rate between the control group and the treatment group (82.0% vs 92.0%, P<0.05); comparison of side effects:there was a significant difference in the incidence rate of side effects between the control group and the treatment group (100.0% vs 54.0%, P<0.05).Conclusion For patients with chronic ITP with Qi failing to control blood, Jianpi Shengxue Decoction can effectively increase platelet count and ameliorate or eliminate the side effects of hormone therapy, so it holds promise for clinical application. |
| Key words: idiopathic thrombocytopenic purpura Qi failing to control blood Jianpi Shengxue Decoction |
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