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柳景红,刘登义,陈振中,李乐平,曹建雄.桃红四物汤对急性深静脉血栓模型大鼠血清IL-6和TNF-α水平的影响[J].湖南中医药大学学报英文版,2019,39(1):32-34.[Click to copy
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| 桃红四物汤对急性深静脉血栓模型大鼠血清IL-6和TNF-α水平的影响 |
| 柳景红,刘登义,陈振中,李乐平,曹建雄 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察桃红四物汤对急性下肢深静脉血栓（deep vein thrombosis，DVT）大鼠血清肿瘤坏死因子-α（tumor-necrosisfactor-α，TNF-α）与白介素-6（interleukin-6，IL-6）水平的影响。方法 将80只雄性SD大鼠随机分为假手术（A）、DVT模型（B）、桃红四物汤（C）、阿司匹林（D）4组，每组20只。A组：只开腹，不结扎股静脉，再灌胃生理盐水；B组：予以结扎近心端左股静脉造模后灌胃生理盐水；C组：予以结扎近心端左股静脉造模后桃红四物汤灌胃给药；D组：予以结扎近心端左股静脉造模后灌胃阿司匹林；7 d后停止灌胃，分别于术前、术后第1天、7天用放射性免疫分析法测定各组血清中TNF-α、IL-6的水平，并进行组间比较。结果 术后第1天、7天，与A组比较，B组血清IL-6和TNF-α水平递增（P<0.05），3个时点间两两比较差异均有统计学意义（P<0.05）；与B组比较，C组IL-6和TNF-α水平均降（P<0.05）。结论 DVT大鼠经桃红四物汤治疗后其血清IL-6和TNF-α水平均明显降低，提示桃红四物汤对深静脉血栓的防治疗效较好，具有抗凝聚、提高纤溶活性的作用。 |
| 关键词: 桃红四物汤 深静脉血栓 白介素-6 肿瘤坏死因子-α |
| DOI：10.3969/j.issn.1674-070X.2019.01.008 |
| Received:December 10, 2017 |
| 基金项目:湖南省科技厅科研项目（2011FJ6055）。 |
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| Effect of Taohong Siwu Decoction on Serum Levels of IL-6 and TNF-α in a Rat Model of Acute Deep Venous Thrombosis |
| LIU Jinghong,LIU Dengyi,CHEN Zhenzhong,LI Leping,CAO Jianxiong |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the effect of Taohong Siwu Decoction on the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats with acute deep venous thrombosis (DVT) of the lower extremities.Methods Eighty male Sprague-Dawley (SD) rats were randomly divided into four groups:sham-operated group (group A), DVT model group (group B), Taohong Siwu Decoction group (group C), and aspirin group (group D), with 20 rats in each group. The rats in group A were given open surgery without femoral vein ligation, and then given intragastric administration of saline. The rats in group B were given proximal ligation of the left femoral vein to establish a DVT model, and then given intragastric administration of saline. The rats in group C were given intragastric administration of Taohong Siwu Decoction after proximal ligation of the left femoral vein for establishing the DVT model. The rats in group D were given intragastric administration of aspirin after proximal ligation of the left femoral vein for establishing the DVT model. The intragastric administration in the rats of all groups was withdrawn 7 days later. The serum levels of TNF-α and IL-6 in the four groups were measured by radioimmunoassay before and at 1 and 7 days after operation, and were compared between the four groups.Results Group B had significantly higher serum levels of IL-6 and TNF-α than group A at 1 and 7 days after operation (P<0.05), and the two proinflammatory cytokines were significantly different between the three time points (P<0.05). However, group C had significantly reduced serum levels of IL-6 and TNF-α compared with group B after operation (P<0.05).Conclusion The serum levels of IL-6 and TNF-α in SD rats with acute DVT decrease significantly after intragastric administration of Taohong Siwu Decoction, suggesting that Taohong Siwu Decoction has good efficacy in preventing and treating DVT, with anticoagulant and fibrinolytic activity. |
| Key words: Taohong Siwu Decoction deep venous thrombosis interleukin-6 tumor necrosis factor-α |
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