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赵用,刘佳,马宝东,陈岩松,张宏,乔敏,甘雨.苓泽合剂对急性痛风性关节炎大鼠血清IL-6、TNF-α含量的影响[J].湖南中医药大学学报英文版,2019,39(1):28-31.[Click to copy
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| 苓泽合剂对急性痛风性关节炎大鼠血清IL-6、TNF-α含量的影响 |
| 赵用,刘佳,马宝东,陈岩松,张宏,乔敏,甘雨 |
| (辽宁中医药大学附属第二医院风湿科, 辽宁 沈阳 110034) |
| 摘要: |
| 目的 观察苓泽合剂对尿酸钠诱导的大鼠痛风性关节炎的抗炎作用，并探讨其作用机制。方法 将80只Wistar大鼠随机分为空白组、模型组、芬必得组、苯溴马隆组、痛风定组及苓泽合剂低、中、高剂量组，每组10只。用尿酸钠诱导大鼠痛风性关节炎，测定血清中白细胞介素-6（interlenkin 6，IL-6）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）的含量。结果 与模型组比较，各给药组血清中IL-6与TNF-α的含量均显著降低（P<0.01）。苓泽合剂中剂量组、高剂量组与低剂量组比较，血清中IL-6、TNF-α的含量明显下降（P<0.05）。结论 苓泽合剂可抑制急性痛风性关节炎大鼠IL-6、TNF-α的表达，治疗痛风性关节炎。 |
| 关键词: 苓泽合剂 痛风性关节炎 IL-6 TNF-α |
| DOI：10.3969/j.issn.1674-070X.2019.01.007 |
| Received:November 14, 2017 |
| 基金项目:辽宁省自然科学基金项目（2013020164）。 |
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| Effect of Lingze Mixture on Serum Levels of IL-6 and TNF-α in Rats with Acute Gouty Arthritis |
| ZHAO Yong,LIU Jia,MA Baodong,CHEN Yansong,ZHANG Hong,QIAO Min,GAN Yu |
| (Department of Rheumatology, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110034, China) |
| Abstract: |
| Objective To explore the anti-inflammatory effect of Lingze Mixture on monosodium urate (MSU) crystal-induced gouty arthritis in rats and its mechanism of action.Methods Eighty Wistar rats were randomly divided into blank group, model group, fenbid group, benzbromarone group, Tongfengding group, and traditional Chinese medicine (TCM) Lingze Mixture groups (low, medium, and high doses), with ten rats in each group. A rat model of gouty arthritis was established by MSU crystals. Then the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined.Results Compared with the model group, levels of IL-6 and TNF-α in serum in each model group were significantly decreased (P<0.01). Compared with the low-dose Lingze Mixture group, the medium-and high-dose Lingze Mixture groups had significantly reduced serum levels of IL-6 and TNF-α (P<0.05).Conclusion Lingze Mixture can inhibit the expression of IL-6 and TNF-α in rats with acute gouty arthritis, thus achieving the aim of preventing and alleviating gouty arthritis. |
| Key words: Lingze Mixture gouty arthritis interleukin-6 tumor necrosis factor-α |
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