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阳晶晶,赵钊,石佳,葛君芸,欧阳里知,常小荣,刘迈兰,黄洁.隔药饼灸对高脂血症合并动脉粥样硬化兔血清TNF-α、INF-γ含量的影响[J].湖南中医药大学学报英文版,2018,38(11):1258-1261.[Click to copy
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| 隔药饼灸对高脂血症合并动脉粥样硬化兔血清TNF-α、INF-γ含量的影响 |
| 阳晶晶,赵钊,石佳,葛君芸,欧阳里知,常小荣,刘迈兰,黄洁 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察隔药饼灸对高脂血症合并动脉粥样硬化兔血清中肿瘤坏死因子α（TNF-α）、干扰素γ（INF-γ）含量的影响，探讨其抗动脉粥样硬化作用的机制。方法 40只新西兰大耳白兔随机分为5组，每组8只，即正常组、模型组、隔药饼灸组、直接灸组、辛伐他汀组。通过高脂饲料喂养建立高脂血症合并动脉粥样硬化兔模型，待造模成功后，除正常组外，其余四组均予以相应干预，每天1次，连续干预4周后，采用酶联免疫吸附法（ELISA）测定兔血清中TNF-a、IFN-γ。结果 与正常组比较，模型组、直接灸组、辛伐他汀组血清TNF-α、IFNγ的含量升高，且差异具有统计学意义（P<0.01或P<0.05）；与模型组相比，直接灸组、辛伐他汀组、隔药饼灸组中血清TNF-α、IFNγ的含量均明显下降，差异具有统计学意义（P<0.01或P<0.05）；隔药饼灸组与正常组相比较，隔药饼灸组的血清IFNγ含量有升高趋势，但差异无统计学意义（P>0.05），TNF-α与正常组相比含量增多，差异具有统计学意义（P<0.05）。结论 隔药饼灸对动脉粥样硬化兔血清相关炎性因子TNF-α、IFN-γ的影响是隔药饼灸抗动脉粥样硬化作用机制之一。 |
| 关键词: 隔药饼灸 高脂血症 动脉粥样硬化 肿瘤坏死因子α 干扰素γ |
| DOI：10.3969/j.issn.1674-070X.2018.11.008 |
| Received:August 09, 2018 |
| 基金项目:国家自然科学基金项目（81273828；81273830；81704182），湖南省自然科学基金项目（2018JJ3397） |
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| Effect of Herbal Cake-Separated Moxibustion on the Expression of Serum TNF-α and INF-γ in Rabbits with Hyperlipidemia and Atherosclerosis |
| YANG Jingjing,ZHAO Zhao,SHI Jia,GE Junyun,OUYANG Lizhi,CHANG Xiaorong,LIU Mailan,HUANG Jie |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the effect of herbal cake-separated moxibustion on the expression of tumor necrosis factor alpha (TNF-α) and interferon gamma (INF-γ) in the serum of rabbits with hyperlipidemia and atherosclerosis, and to investigate the mechanism of its anti-atherosclerotic effect. Methods A total of 40 New Zealand white rabbits were randomly divided into five groups, namely blank control group (normal group), model group, herbal cake-separated moxibustion group, direct moxibustion group, and simvastatin group, with eight rabbits in each group. A hyperlipidemia and atherosclerosis rabbit model was established by feeding high-fat diet to the animals. After successful modeling, all the five groups, except the blank control group, received corresponding treatment once a day for four successive weeks; then enzyme-linked immunosorbent assay was used to determine the levels of TNF-α and IFN-γ in the serum of the rabbits. Results The expression levels of TNF-α and IFN-γ in the serum increased significantly in the model group, the direct moxibustion group, and the simvastatin group compared with those in the normal group (P<0.01 or P<0.05); the serum levels of TNF-α and IFN-γ decreased significantly in the direct moxibustion group, the simvastatin group, and the herbal cake-separated moxibustion group compared with that in the model group (P<0.01 or P<0.05); compared with the normal group, the herbal cake-separated moxibustion group had a significantly increased expression level of serum TNF-α (P<0.05), but there was no significant difference between the two groups in the serum level of IFN-γ despite an increasing trend in the herbal cake-separated moxibustion group (P>0.05). Conclusion The effect on relevant inflammatory factors (TNF-α and IFN-γ) in the serum of atherosclerotic rabbits is one of the anti-atherosclerotic mechanisms of herbal cake-separated moxibustion. |
| Key words: herbal cake-separated moxibustion hyperlipidemia atherosclerosis tumor necrosis factor alpha interferon gamma |
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