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梁桂林.龙蛭汤治疗气虚血瘀型急性脑梗死的临床疗效及其机制探讨[J].湖南中医药大学学报英文版,2018,38(10):1191-1194.[Click to copy
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| 龙蛭汤治疗气虚血瘀型急性脑梗死的临床疗效及其机制探讨 |
| 梁桂林 |
| (山东省菏泽市中医医院脑病科, 山东 菏泽 274000) |
| 摘要: |
| 目的 探析龙蛭汤治疗气虚血瘀型急性脑梗死的临床疗效及其可能作用机制。方法 选取88例急性脑梗死患者，按随机数字表法分为观察组与对照组，每组各44例。对照组予以常规西医疗法，观察组在对照组基础上联合龙蛭汤进行治疗。比较两组治疗总有效率、治疗前后中医证候积分（主症积分、次症积分与总积分）、血清低氧诱导因子-1α（HIF-1α）、血管内皮生长因子（VEGF）、血管生长素-2（Ang-2）水平，记录两组治疗期间不良反应发生情况。结果 观察组治疗总有效率为79.5%，显著高于对照组59.1%（P<0.05）。与治疗前比较，两组治疗后的中医证候积分、血清VEGF、HIF-1α水平均降低，而血清Ang-2水平升高（P<0.05）；与对照组比较，观察组的中医证候积分、血清VEGF、HIF-1α水平降低，而血清Ang-2水平升高（P<0.05或P<0.01）。观察组与对照组不良反应总发生率分别为6.82%与2.27%，两组比较差异无统计学意义（P>0.05）。结论 龙蛭汤治疗气虚血瘀型急性脑梗死可益气活血、逐瘀通络，通过调控血管新生因子表达而促血管新生，改善患者症状，安全可靠，值得推广。 |
| 关键词: 急性脑梗死 龙蛭汤 气虚血瘀型 |
| DOI：10.3969/j.issn.1674-070X.2018.10.022 |
| Received:November 29, 2017 |
| 基金项目:山东省科技计划项目（1401025019）。 |
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| Clinical Efficacy and Mechanism of Action of Longzhi Decoction in Treatment of Acute Cerebral Infarction with Qi Deficiency and Blood Stasis |
| LIANG Guilin |
| (Department of Encephalopathy, Heze Hospital of Traditional Chinese Medicine, Heze, Shandong 274000, China) |
| Abstract: |
| Objective To investigate the clinical efficacy and possible mechanism of action of Longzhi Decoction in the treatment of acute cerebral infarction with Qi deficiency and blood stasis. Methods A total of 88 patients with acute cerebral infarction were equally and randomly divided into observation group and control group using a random number table. The control group was given conventional Western medicine, while the observation group was given Longzhi Decoction in addition to the treatment for the control group. The overall response rate, as well as the traditional Chinese medicine (TCM) syndrome scores (main symptom score, secondary symptom score, and total score), serum levels of hypoxia-inducible factor 1α (HIF-1α), vascular endothelial growth factor (VEGF), and angiopoietin-2 (Ang-2) before and after treatment, were compared between the two groups. The adverse events during the treatment in the two groups were recorded. Results The observation group had a significantly higher overall response rate than the control group (79.5% vs 59.1%, P<0.05). After treatment, both groups showed significantly decreased TCM syndrome scores and serum levels of VEGF and HIF-1α and a significantly increased serum level of Ang-2 (P<0.05); compared with the control group, the observation group had significantly lower TCM syndrome scores and serum levels of VEGF and HIF-1α and a significantly higher serum level of Ang-2 (P<0.05 or P<0.01). There was no significant difference in the overall incidence rate of adverse events between the observation group and the control group (6.82% vs 2.27%, P>0.05). Conclusion Longzhi Decoction has Qi-tonifying, blood circulation-activating, stasis-expelling, and collateral-dredging effects in the treatment of acute cerebral infarction with Qi deficiency and blood stasis. It can promote angiogenesis by regulating angiogenic factor expression and improve the symptoms of patients, and is safe and reliable, so it holds promise for clinical application. |
| Key words: acute cerebral infarction Longzhi Decoction Qi deficiency and blood stasis |
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