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刘应科,杨晔,王秋莉,范菲,麻建辉,刘文,高晓宇,王霞,柯木林.小儿消脂方治疗脾虚湿盛型单纯性肥胖症患儿临床疗效观察[J].湖南中医药大学学报英文版,2018,38(9):1052-1057.[Click to copy
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| 小儿消脂方治疗脾虚湿盛型单纯性肥胖症患儿临床疗效观察 |
| 刘应科,杨晔,王秋莉,范菲,麻建辉,刘文,高晓宇,王霞,柯木林 |
| (北京市和平里医院, 北京 100013;北京首儿李桥儿童医院, 北京 101314;北京首儿药厂, 北京 101304) |
| 摘要: |
| 目的 观察小儿消脂方治疗脾虚湿盛型单纯性肥胖症患儿的临床疗效。方法 采用随机对照的研究方法，将符合标准的68例患儿随机分为对照组33例和治疗组35例，对照组采用饮食和运动干预，治疗组在对照组的基础上服用小儿消脂方，每日2次，疗程为12周。治疗前后记录患者的体质量、身高、体质量指数（BMI）、血压、黑棘皮情况，检测生化全项指标，检查腹部B超。结果 两组综合比较，对照组总有效率54.55%；治疗组总有效率为91.43%，明显高于对照组（P<0.05）；肥胖儿童黑棘皮发生情况在治疗前组间无差异（P>0.05），治疗后两组均有下降，但治疗组明显下降，组间存在统计学差异（P<0.01）；体质量治疗后均有下降趋势，但治疗组下降明显，组间存在统计学差异（P<0.05）；身高增长无统计学差异（P>0.05）；治疗组血压治疗后有下降趋势，且组间存在统计学差异（P<0.05）；ALT、AST在治疗后有下降趋势，且存在组间差异（P<0.05），BUN、CR治疗前后均无组间差异（P>0.05）；TC、TG、HDL-C、LDL-C在治疗后均有所改善，且存在组间差异（P<0.05），FFA治疗前后无组间差异（P>0.05）。空腹血糖治疗后改善，存在组间差异（P<0.01），对照组患儿脂肪肝情况无改善，治疗组患儿脂肪肝均消失，组间存在统计学差异（P<0.01）。结论 小儿消脂方治疗脾虚湿盛型单纯性肥胖症患儿具有一定的作用，疗效明显优于单纯饮食和运动干预。 |
| 关键词: 儿童单纯性肥胖 脾虚湿盛 小儿消脂方 体质量指数 血脂 |
| DOI：10.3969/j.issn.1674-070X.2018.09.019 |
| Received:June 04, 2018 |
| 基金项目:北京市科协金桥基金（201610328）。 |
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| Clinical Effect of Xiaoer Xiaozhi Prescription in Treatment of Simple Obesity with Spleen Deficiency and Dampness Excess in Children |
| LIU Yingke,YANG Ye,WANG Qiuli,FAN Fei,MA Jianhui,LIU Wen,GAO Xiaoyu,WANG Xia,KE Mulin |
| (Beijing Hepingli Hospital, Beijing 100013, China;Beijing Shouer Liqiao Children's Hospital, Beijing 101314, China;Beijing Shouer Pharmaceutical Factory, Beijing 101304, China) |
| Abstract: |
| Objective To investigate the clinical effect of Xiaoer Xiaozhi prescription in the treatment of children with simple obesity with spleen deficiency and dampness excess. Methods A total of 68 children who met the inclusion criteria were enrolled in this randomized controlled trial and randomly divided into control group with 33 children and treatment group with 35 children. The children in the control group were given diet and exercise intervention, and those in the treatment group were given Xiaoer Xiaozhi prescription twice a day for 12 weeks in addition to the treatment in the control group. Before and after treatment, body weight, body height, body mass index, blood pressure, and the condition of acanthosis nigricans were recorded, biochemical indices were measured, and abdominal ultrasound was performed. Results The treatment group had a significantly higher overall response rate than the control group (91.43% vs 54.55%, P<0.05). Before treatment, there was no significant difference in the incidence rate of acanthosis nigricans between the two groups (P>0.05); after treatment, both groups showed a reduction in the incidence rate of acanthosis nigricans and the treatment group had a significantly greater reduction than the control group (P<0.01). Both groups had a reduction in body weight after treatment, and the treatment group had a significantly greater reduction than the control group (P<0.05). There was no significant difference in the increase in body height between the two groups (P>0.05). The treatment group had a reduction in blood pressure after treatment, and there was a significant difference between the two groups (P<0.05). There were reductions in alanine aminotransferase and aspartate aminotransferase after treatment, and there were significant differences between the two groups (P<0.05). There were no significant differences in blood urea nitrogen and creatinine between the two groups before and after treatment (P>0.05). Both groups showed improvements in total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after treatment, and there were significant differences between the two groups (P<0.05); there was no significant difference in free fatty acid between the two groups before and after treatment (P>0.05). Both groups had an improvement in fasting blood glucose after treatment and there was a significant difference between the two groups (P<0.01). The control group showed no improvement in fatty liver disease, while the treatment group showed disappearance of fatty liver disease; there was a significant difference between the two groups (P<0.01). Conclusion Xiaoer Xiaozhi prescription has a certain effect in the treatment of simple obesity with spleen deficiency and dampness excess, with a significantly better clinical effect than diet and exercise intervention alone. |
| Key words: simple obesity in children spleen deficiency and dampness excess Xiaoer Xiaozhi prescription body mass index blood lipid |
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