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梁玉清,韩莉,梁紫恩,买娟娟,李玲玉.健脾化痰类中药联合降糖西药治疗超重/肥胖2型糖尿病的Meta分析[J].湖南中医药大学学报英文版,2018,38(9):1043-1048.[Click to copy
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| 健脾化痰类中药联合降糖西药治疗超重/肥胖2型糖尿病的Meta分析 |
| 梁玉清,韩莉,梁紫恩,买娟娟,李玲玉 |
| (暨南大学中医学院, 广东 广州 510632;暨南大学附属第一医院, 广东 广州 510632) |
| 摘要: |
| 目的 通过Meta分析，对健脾化痰类中药联合降糖西药治疗超重/肥胖2型糖尿病的临床疗效进行评价。方法 检索中国知网数据库、维普期刊全文数据库、万方数据库、中国生物医学文献数据库及PubMed等5个数据库，检索时间均从建库起至2018年3月，筛选出符合纳入标准的临床随机对照试验，采用Revman 5.3软件进行Meta分析。结果 健脾化痰类中药联合降糖西药的临床有效率优于单纯降糖西药治疗[OR=4.17，95% IC（2.46，7.07），P<0.000 01]；在改善血糖方面优于单纯降糖西药治疗，空腹血糖（FPG）[MD=-0.66，95% IC（-1.04，-0.27），P=0.0008]、餐后2小时血糖（2hPG）[MD=-1.56，95% IC（-2.19，-0.93），P<0.000 01]、糖化血红蛋白（HbA1C）[MD=-0.38，95% IC（-0.48，-0.28），P<0.000 01]；在降低体质量指数（BMI）方面明显优于单纯降糖西药治疗[MD=-1.98，95% IC（-3.16，-0.79），P=0.01]。结论 健脾化痰类中药联合降糖西药治疗超重/肥胖2型糖尿病患者在临床有效率、改善血糖方面均优于单纯的降糖西药治疗，但现有的文献质量较低，仍需高质量的随机对照试验来证实该结论。 |
| 关键词: 2型糖尿病 健脾化痰 超重 肥胖 Meta分析 |
| DOI：10.3969/j.issn.1674-070X.2018.09.017 |
| Received:March 08, 2018 |
| 基金项目:广东省财政共建支持项目"中医重点实验室建设"（89017020）。 |
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| Clinical Efficacy of Spleen-Invigorating and Phlegm-Removing Traditional Chinese Medicine Combined with Hypoglycemic Western Medicine in Treatment of Overweight/Obese Type 2 Diabetes Mellitus:A Meta-analysis |
| LIANG Yuqing,HAN Li,LIANG Zien,MAI Juanjuan,LI Lingyu |
| (College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China;The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy of spleen-invigorating and phlegm-removing traditional Chinese medicine (TCM) combined with hypoglycemic Western medicine in the treatment of overweight/obese type 2 diabetes mellitus (T2DM) by meta-analysis. Methods A literature search was performed in CNKI, VIP, Wanfang Data, CBM, and PubMed to collect the clinical randomized controlled trials (RCTs) that met the inclusion criteria published up to March 2018. And then a meta-analysis was performed on the included RCTs using RevMan 5.3 software. Results Compared with the hypoglycemic Western medicine alone group, the spleen-invigorating and phlegm-removing TCM combined with hypoglycemic Western medicine group had a significantly higher overall response rate (odds ratio[OR]=4.17, 95% confidence interval[CI]:2.46-7.07, P<0.000 01), significantly more improvements in fasting blood glucose (mean difference[MD]=-0.66, 95% CI:-1.04 to -0.27, P=0.000 8), 2-hour postprandial blood glucose (MD=-1.56, 95% CI:-2.19 to -0.93, P<0.000 01), and glycosylated hemoglobin (MD=-0.38, 95% CI:-0.48 to -0.28, P<0.000 01), and a significantly greater reduction in body mass index (MD=-1.98, 95% CI:-3.16 to -0.79, P=0.01). Conclusion Compared with hypoglycemic Western medicine alone, spleen-invigorating and phlegm-removing TCM combined with hypoglycemic Western medicine can increase the overall response rate and improve blood glucose in patients with overweight or obese T2DM. However, the quality of the existing literature is relatively low, and the conclusion needs to be confirmed by high-quality RCTs. |
| Key words: type 2 diabetes mellitus spleen-invigorating and phlegm-removing overweight obesity meta-analysis |
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