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熊慧生.自拟中药方联合化疗方案对乳腺癌患者免疫功能指标水平及生活质量的影响[J].湖南中医药大学学报英文版,2018,38(8):925-929.[Click to copy
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| 自拟中药方联合化疗方案对乳腺癌患者免疫功能指标水平及生活质量的影响 |
| 熊慧生 |
| (重庆大学附属肿瘤医院, 重庆 400030) |
| 摘要: |
| 目的 研究自拟中药汤剂联合化疗方案治疗对乳腺癌患者免疫功能指标水平和生活质量的影响。方法 选取2017年6月至2018年2月本院收治的均为初诊原发性乳腺癌的化疗患者112例，按随机数字表法分为观察组和对照组，每组56例。对照组予以常规CTF化疗方案治疗，观察组在对照组的化疗方案的基础上予以口服自拟中药汤剂。观察治疗前后患者的T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）的变化，检测血常规[白细胞（WBC）、血红蛋白（Hb）和血小板（PLT）计数]，采用SF-36量表进行生活质量评分；并且在治疗后判定临床疗效。结果 （1）观察组患者的CD3+、CD4+、CD4+/CD8+水平高于治疗前，对照组CD4+、CD4+/CD8+水平亦高于治疗前，差异均有统计学意义（P<0.05或P<0.01）；且治疗后观察组患者的CD3+、CD4+、CD4+/CD8+水平高于对照组（P<0.05）。（2）两组患者WBC、Hb和PLT计数均较治疗前下降（P<0.05或P<0.01）；且治疗后观察组WBC和PLT计数均高于对照组（P<0.05）。（3）两组患者8个维度评分均较治疗前升高（P<0.05）；且治疗后除情绪角色外，观察组其余7个维度评分均高于对照组（P<0.05）。（4）观察组总有效率为83.93%，高于对照组的71.43%，差异有统计学意义（P<0.05）。结论 中药汤剂配合化疗对乳腺癌患者的免疫功能和生活质量都有很大改善，提高了T淋巴细胞亚群水平，临床效果显著。 |
| 关键词: 乳腺癌 化疗 中药方 T淋巴细胞亚群 SF-36量表 白细胞 |
| DOI：10.3969/j.issn.1674-070X.2018.08.020 |
| Received:May 21, 2018 |
| 基金项目:四川省卫生厅资助项目（160075）。 |
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| Effect of a Self-made Traditional Chinese Medicine Prescription Combined with Chemotherapy on Immune Function Parameters and Quality of Life in Breast Cancer Patients |
| XIONG Huisheng |
| (The Affiliated Tumor Hospital of Chongqing University, Chongqing 400030, China) |
| Abstract: |
| Objective To investigate the effect of a self-made traditional Chinese medicine (TCM) decoction combined with chemotherapy on immune function parameters and quality of life in patients with breast cancer. Methods A total of 112 patients with primary breast cancer who were admitted to our hospital from June 2017 to February 2018 and underwent chemotherapy were enrolled and divided into observation group and controlgroup using a random number table, with 56 patients in each group. The patients in the control group were given conventional CTF chemotherapy, and those in the observation group were given a self-made TCM decoction orally in addition to the chemotherapy in the control group. The changes in T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+ ratio) after treatment were observed; routine blood tests were performed, including white blood cell count (WBC), hemoglobin (Hb), and platelet count (PLT); the 36-Item Short-Form Health Survey (SF-36) scale was used to determine quality-of-life score; the clinical outcome was evaluated after treatment. Results After treatment, the observation group had significant increases in the percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio and the control group had significant increases in the percentage of CD4+ T lymphocytes and CD4+/CD8+ ratio (P<0.05 or P<0.01), and the observation group had significantly higher percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio than the control group(P<0.05). Both groups had significant reductions in WBC, Hb, and PLT after treatment(P<0.05 or P<0.01), and the observation group had significantly higher WBC and PLT than the control group(P<0.05). Both groups had significant increases in the scores of the eight dimensions of the SF-36 scale after treatment(P<0.05), and the observation group had significantly higher scores of all dimensions except role emotional than the control group(P<0.05). The observation group had a significantly higher overall response rate than the control group (83.93% vs 71.43%, P<0.05). Conclusion TCM decoction combined with chemotherapy has a good clinical effect in the treatment of patients with breast cancer and can greatly improve their immune function and quality of life and increase the percentages of T lymphocyte subsets. |
| Key words: breast cancer chemotherapy traditional Chinese medicine prescription T lymphocyte subset 36-Item Short-Form Health Survey scale white blood cell |
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