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李洵,王东生,姚叶.葛根交泰丸对2型糖尿病大鼠血清炎症因子的影响[J].湖南中医药大学学报英文版,2018,38(6):624-628.[Click to copy
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| 葛根交泰丸对2型糖尿病大鼠血清炎症因子的影响 |
| 李洵,王东生,姚叶 |
| (中南大学湘雅医院中西医结合科, 湖南 长沙 410008) |
| 摘要: |
| 目的 观察葛根交泰丸对2型糖尿病大鼠血清炎症因子的影响，探讨其治疗2型糖尿病的可能机制。方法 采用高脂高糖和小剂量链脲佐菌素（STZ）诱发2型糖尿病大鼠动物模型。将造模成功大鼠随机分为模型组，西药组，中药组，每组10只，另设健康大鼠10只为正常组。西药组予以罗格列酮4 mg/（kg·d）灌胃，中药组予以葛根交泰丸4.6 g/（kg·d）灌胃，正常组及模型组予以等容量生理盐水，每天1次。6周后，监测大鼠空腹血糖（FPG）、餐后2 h血糖（2 hPPG）、胰岛素敏感指数和血清炎症因子水平，并观察胰岛组织HE染色切片。结果 与正常组相比，模型组大鼠FBG、2 hPPG和血清炎症因子水平显著升高（P<0.01，P<0.05），胰岛素敏感指数显著降低（P<0.01，P<0.05），胰岛组织形态破坏严重。与模型组相比，葛根交泰丸组大鼠FPG、2 hPPG和血清炎症因子水平显著降低（P<0.01，P<0.05），胰岛素敏感指数显著升高（P<0.01，P<0.05），胰岛组织形态有明显改善。结论 葛根交泰丸的降糖作用机制可能与降低2型糖尿病大鼠血清炎症因子水平，进而改善胰岛素抵抗和修复受损胰岛组织细胞有关。 |
| 关键词: 2型糖尿病 胰岛素抵抗 炎症因子 葛根交泰丸 血糖 |
| DOI：10.3969/j.issn.1674-070X.2018.06.004 |
| Received:November 17, 2017 |
| 基金项目:国家自然科学基金项目（81173198，81373554），国家科技部国际合作计划（2010DFA32370）。 |
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| Effect of Gegen Jiaotai Pills on Inflammatory Factors of Type 2 Diabetes Rats |
| LI Xun,WANG Dongsheng,YAO Ye |
| (Department of Integrated of Traditional Chinese and Western Medicine, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China) |
| Abstract: |
| Objective To observe the effect of Gegen Jiaotai pills on inflammatory factors of type 2 diabetes rats, and to explore possible action mechanism of Gegen Jiaotai pills in treating type 2 diabetes. Methods Type 2 diabetes mellitus rat model was established by high fat diet combined with intraperitoneal injection of streptozotocin(STZ). The successful model rats were randomly divided into model group, Western medicine group and traditional Chinese medicine group, with 10 rats in each group. Another 10 healthy rats were set as normal group. Western medicine group was perfused with rosiglitazone 4 mg/(Kg·d), traditional chinese medicine group was perfused with Gegen Jiaotai pills 4.6 g/(Kg·d), normal and model groups were perfused with the same volume of saline as the criteria of body volume, once daily. After 6 weeks, the FBG, OGTT 2 h, insulin sensitivity index and inflammatory factors were measured in earch group, meanwhile the histopathological changes of pancreas was observed by HE staining. Results Compared with the normal group, the levels of FPG, OGTT 2 h and inflammatory factors in the model group increased obviously (P<0.01, P<0.05), while the insulin sensitivity index declined obviously (P<0.01, P<0.05), and the morphology of pancreas was seriously damaged in model group. Compared with the model group, the levels of FPG, OGTT 2 h and inflammatory factors decreased obviously (P<0.01, P<0.05), the insulin sensitivity index elevated obviously (P<0.01, P<0.05), and the morphology of pancreas islet were significantly improved. Conclusion The hypoglycemic effect of Gegen Jiaotai pills may be related to reducing the level of inflammation factors of type 2 diabetes rats for improving insulin resistance and protecting the impaired pancreas. |
| Key words: type 2 diabetes insulin resistance inflammation factors Gegen Jiaotai pills blood glucose |
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