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王华,孟盼,陈鸣凤,张素英.双黄花片对急性上呼吸道感染患者炎症因子及免疫功能的影响[J].湖南中医药大学学报英文版,2018,38(5):570-573.[Click to copy
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| 双黄花片对急性上呼吸道感染患者炎症因子及免疫功能的影响 |
| 王华,孟盼,陈鸣凤,张素英 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208;长沙市八医院, 湖南 长沙 410100) |
| 摘要: |
| 目的 探讨双黄花片对急性上呼吸道感染患者炎症因子和免疫功能的影响。方法 将72例受试者按1：1的比例，随机分为双黄花片治疗组和感冒清片对照组，疗程5 d；观察急性上呼吸道感染疾病的临床疗效，采用双抗体夹心ABC-ELISA法测定血清炎症因子IL-2、IL-6、IL-8、TNF-α含量，流式细胞仪（FACS Calibur）检测外周血T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+水平。结果 经治疗后，治疗组疾病综合疗效明显高于对照组（P<0.01）。治疗组患者血清炎症因子IL-2、IL-6、IL-8、TNF-α水平明显低于对照组，差异有统计学意义（P<0.05）。治疗组患者的T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+水平明显高于对照组，差异有统计学意义（P<0.05）。结论 双黄花片治疗急性上呼吸道感染有较好的疗效，可降低炎症因子水平，提高机体免疫能力。 |
| 关键词: 急性上呼吸道感染 风热证 双黄花片 炎症因子 免疫功能 |
| DOI：10.3969/j.issn.1674-070X.2018.05.021 |
| Received:December 12, 2017 |
| 基金项目:湖南省高校创新平台开放基金项目（13K075）。 |
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| Effect of Shuanghuanghua Tablet on Inflammatory Factors and Immune Function in Patients with Acute Upper Respiratory Infection |
| WANG Hua,MENG Pan,CHEN Mingfeng,ZHANG Suying |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Eighth Hospital of Changsha, Changsha, Hunan 410100, China) |
| Abstract: |
| Objective To explore the effect of Shuanghuanghua tablet on inflammatory factors and immune function in patients with acute upper respiratory infection. Methods A randomized method was used to divide 72 subjects into the treatment group (Shuanghuanghua tablet) and the control group (Ganmaoqing tablet), according to the proportion of 1:1, with a course of 5 days. The clinical efficacy of acute upper respiratory tract infection was observed. The serum inflammatory factors interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 8 (IL-8) and tumor necrosis factor alpha (TNF-α) were determined by double-antibody sandwich ABC-ELISA. The level of T cell subsets of peripheral blood CD3+, CD4+, CD8+ and CD4+/CD8+ was detected by Flow cytometry (FACS Calibur). Results After treatment, the curative effect of the treatment group was significantly higher than the control group (P<0.01). The levels of serum inflammatory factors IL-2, IL-6, IL-8 and TNF-α in the treatment group were significantly lower than the control group, the difference was statistically significant (P<0.05). The T-cell subgroup CD3+, CD4+, CD8+ and CD4+/CD8+ in the treatment group were significantly higher than the control group, the difference was statistically significant (P<0.05). Conclusion Shuanghuanghua tablet has a good therapeutic effect on acute upper respiratory infection, which can reduce the level of inflammatory factors and improve the immune ability of the body. |
| Key words: acute upper respiratory infection wind-heat syndrome Shuanghuanghua tablet inflammatory factors immune function |
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