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杨学芳,李晨,王艳梅.健脾消积汤辅助乳腺癌术后化疗对患者营养及免疫状态的影响[J].湖南中医药大学学报英文版,2018,38(4):463-466.[Click to copy
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| 健脾消积汤辅助乳腺癌术后化疗对患者营养及免疫状态的影响 |
| 杨学芳,李晨,王艳梅 |
| (昆明医科大学第一附属医院, 云南 昆明 650032) |
| 摘要: |
| 目的 观察健脾消积汤辅助乳腺癌术后化疗对患者营养及免疫状态的影响。方法 选取74例乳腺癌患者，按随机数字表法分为观察组与对照组，各37例。对照组术后予以常规抗肿瘤药物治疗，观察组在对照组基础上联合健脾消积汤治疗，两组治疗时间均为18周。比较两组治疗前后的白蛋白（ALB）、血红蛋白（Hb）、体质量指数（BMI）、肱三头肌皮褶厚度（TSF）、CD3+、CD4+、CD8+、CD4+/CD8+、不良反应等观察指标。结果 两组治疗前的血清ALB、Hb、BMI及TSF差异无统计学意义（P>0.05）；观察组治疗后的血清ALB、Hb、BMI及TSF均显著高于对照组。两组治疗前CD3+、CD4+、CD8+、CD4+/CD8+的差异无统计学意义（P>0.05）；观察组治疗后的CD3+、CD4+、CD4+/CD8+均显著高于对照组（P<0.05）。两组肝、肾毒性总发生率的差异无统计学意义（P>0.05）；观察组白细胞下降、血小板下降、胃肠道反应程度均显著轻于对照组（P<0.05），总发生率分别为27.03%，18.92%，32.43%，显著低于对照组59.46%，51.35%，70.27%（P<0.05）。结论 健脾消积汤辅助化疗可有效增强机体免疫力，改善患者营养状态并减轻化疗毒副反应，值得推广。 |
| 关键词: 乳腺癌 健脾消积汤 化疗 营养 免疫状态 |
| DOI：10.3969/j.issn.1674-070X.2018.04.025 |
| Received:November 30, 2017 |
| 基金项目:云南省科技厅—昆明医科大学应用基础研究联合基金（2015FB025）。 |
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| Effects of Jianpi Xiaoji Decoction on Nutritional and Immune Status in Breast Cancer Patients for Adjuvant Chemotherapy |
| YANG Xuefang,LI Chen,WANG Yanmei |
| (The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China) |
| Abstract: |
| Objective To observe the effect of Jianpi Xiaoji decoction on the nutrition and immune status in breast cancer patients for adjuvant chemotherapy. Methods A total of 74 cases of breast cancer patients were selected and randomly divided into the observation group and control group according to random number table method, 37 cases in each group. The control group was treated with conventional anti-tumor drugs, and the observation group was treated with Jianpi Xiaoji decoction on the basis of the control group. The time of treatment was for 18 weeks. The albumin (ALB), hemoglobin (Hb), body mass index (BMI), triceps skinfold (TSF), CD3+, CD4+, CD8+, CD4+/CD8+, adverse reactions were compared between two groups. Results There were no statistical significance in the serum levels of ALB, Hb and BMI, TSF before treatment between two groups (P>0.05). The levels of ALB, Hb, BMI and TSF in the observation group were not statistically significant (P>0.05). There were no significant differences in the levels of CD3+, CD4+, CD8+, CD4+/CD8+ between the two groups before treatment(P>0.05). The CD3+, CD4+, CD4+/CD8+ in the observation group were significantly higher than the control group(P<0.05). There was no significant difference in the total incidence of liver and kidney toxicity bet ween the two groups(P>0.05). The level of reaction leukopenia, thrombocytopenia, gastrointestinal reactions in observation group were significantly lighter than those in the control group (P<0.05). The total incidence of observation group was 27.03%, 18.92% and 32.43% respectively, which was significantly lower than 59.46%, 51.35% and 70.27% of the control group (P<0.05). Conclusion Jianpi Xiaoji decoction for adjuvant chemotherapy could effectively enhance immunity and improve patient nutrition status, worthy of promoting. |
| Key words: breast cancer Jianpi Xiaoji decoction chemotherapy nutrition immune status |
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