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刘华,陈国铭,綦向军,梁妙珍,陈腾宇,张洁,田燕华,冯惜怡,张琳琳,陈子茵,许华.基于数据挖掘的许华教授治疗过敏性紫癜用药规律探讨[J].湖南中医药大学学报英文版,2018,38(4):430-434.[Click to copy
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| 基于数据挖掘的许华教授治疗过敏性紫癜用药规律探讨 |
| 刘华,陈国铭,綦向军,梁妙珍,陈腾宇,张洁,田燕华,冯惜怡,张琳琳,陈子茵,许华 |
| (广州中医药大学第一附属医院, 广东 广州 510405;广州中医药大学第一临床医学院, 广东 广州 510405;广州中医药大学第二临床医学院, 广东 广州 510405) |
| 摘要: |
| 目的 基于数据挖掘技术，探讨许华教授治疗过敏性紫癜（henoch-schonlein purpura，HSP）的用药规律，为更好地继承其学术经验提供量化的数据支持。方法 收集整理许华教授治疗HSP的验案，录入中医传承辅助平台构建数据库，运用规则分析、改进互信息法、复杂系统熵聚类、网络拓扑学等数据挖掘方法进行统计分析。结果 对纳入的164个病案和233个处方进行分析，提取主要临床表现和核心用药组合规律，结果显示频次排列前6的临床表现有肺（-）、二便调、纳可、苔白、咽（-）、咽（+）；频次排列前10的核心药物有紫苏叶、赤芍、蝉蜕、防风、紫草、生地黄、牡丹皮、白豆蔻、茜草、连翘、白茅根，以疏风解表、清热解毒、凉血化瘀类药物为主；并衍生出3个新方，新方针对皮疹、肾损害等临床表现各有侧重。结论 许华教授治疗HSP以清热凉血、祛风化瘀为主，常辅以理气化湿之品，体现其"HSP发病必与外邪相关"的辨证思想和"以清为主"的临证经验。 |
| 关键词: 过敏性紫癜 用药规律 数据挖掘 中医传承辅助平台 许华 |
| DOI：10.3969/j.issn.1674-070X.2018.04.017 |
| Received:December 06, 2017 |
| 基金项目:广州中医药大学中医学术流派传承项目：岭南黎氏儿科学术流派（2015LP03）。 |
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| Medication Regularity of XU Hua in Treating Allergic Purpura Based on Data Mining |
| LIU Hua,CHEN Guoming,QI Xiangjun,LIANG Miaozhen,CHEN Tengyu,ZHANG Jie,TIAN Yanhua,FENG Xiyi,ZHANG Linlin,CHEN Ziyin,XU Hua |
| (The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China;The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China;The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China) |
| Abstract: |
| Objective Based on data mining technology, medication rules of Professor XU Hua in treatment of allergic purpura were investigated, to provide quantitative data support for better inheriting her academic experience. Methods The cases of professor XU Hua in treatment of allergic purpura were collected, data was put into TCM inheritance support system to build database. The principle analysis, improved mutual information method, complex system entropy clustering, topology of network and other data mining methods were used for statistical analysis. Results The 164 medical records and 233 prescriptions were analyzed, and the main symptoms and combination rules of core herbs were extracted. The results showed that the symptoms of the first 6 were lung (-), diaphane, naoko, liverwort, pharynx(-), and pharynx(+). The core of the frequency of the top 10 drugs have purple perilla leaf (Zisuye), red paeony root (Chishao), periostracum cicada (Chantui), windproof (Fangfeng), radix arnebiae seu lithospermi (Zicao), radix rehmanniae (Shengdihuang), cortex moutan (Mudanpi), white cardamom (Baidoukou), madder (Qiancao), forsythia (Lianqiao), cogongrass rhizome (Baimaogen). The main functions of the medicines were reducing the wind to nourish, heat-clearing and detoxifying, cooling blood to remove stasis. Three new prescriptions were also derived, which mainly focused on the symptoms of rashes and kidney damage. Conclusion The medicines of clearing heat and cooling blood (Qingre Liangxue), dispelling wind and expelling blood stasis (Qufeng Huayu) were commonly used by Professor XU Hua in treating allergic purpura. It is often accompanied by the herbs of regulating Qi and transforming dampness, which reflects the dialectical thought of "the pathogenesis of allergic purpura associated with exogenous pathogenic factors" and the experience of "mainly using the method of eliminatin". |
| Key words: allergic purpura medication regularity data mining traditional Chinese medicine inheritance support system XU Hua |
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