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贺冰,刘晓丹,李亮,李平,张伟.整合素αvβ3介导EPCs修复损伤血管内皮及补阳还五汤的干预作用[J].湖南中医药大学学报英文版,2018,38(3):261-265.[Click to copy
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| 整合素αvβ3介导EPCs修复损伤血管内皮及补阳还五汤的干预作用 |
| 贺冰,刘晓丹,李亮,李平,张伟 |
| (湖南中医药大学第二附属医院, 湖南 长沙 410005;中医药防治心脑血管疾病湖南省重点实验室, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208;湖南中医药大学中西医结合学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 探讨补阳还五汤促进EPCs修复损伤血管内皮的作用，从归巢环节阐释其作用机制，为中医药防治心脑血管疾病提供参考。方法 以补阳还五汤灌胃及尾静脉输注EPCs作用于内皮损伤的模型大鼠，从血管内皮形态、EPCs归巢等方面评价内皮损伤修复情况，从整合素αvβ3和αvβ5介导的SDF-1/CXCR-4信号通路了解该方促进EPCs归巢的机制。结果 与单用EPC组（E组）和单用药物组（b组）比较，补阳还五汤联合EPC组（B组）αvβ3表达显著增加（P<0.05），血管SDF-1表达显著增高（P<0.01）。结论 补阳还五汤能促进EPC修复损伤的血管内皮，其作用机制可能与该方能上调整合素αvβ3介导的SDF-1信号通路相关蛋白，促进EPCs的归巢有关。 |
| 关键词: 整合素αvβ3 整合素αvβ5 内皮祖细胞 补阳还五汤 归巢 |
| DOI：10.3969/j.issn.1674-070X.2018.03.008 |
| Received:December 04, 2017 |
| 基金项目:国家自然科学基金资助项目（81001494）；湖南省教育厅重点实验室开放基金项目（15k059）；湖南省自然科学基金项目（2016JJ4069）。 |
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| Intervention Effect of Buyang Huanwu Decoction on Integrin αvβ3-Mediated EPCs in Repairing Damaged Vascular Endothelium |
| HE Bing,LIU Xiaodan,LI Liang,LI Ping,ZHANG Wei |
| (The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China;Hunan Key Laboratory of TCM Prevention and Treatment of Cardiovascnlar and Cerebrovascular Diseases, Changsha, Hunan 410005, China;College of Traditional Chinese Medicine, Hunan University of Chinsese Medicine, Changsha, Hunan 410208, China;College of Integrated Chinese and Western medicines, Hunan University of Chinsese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To investigate the role of Buyang Huanwu decoction (BYHWD) in promoting endothelial progenitor cell (EPC)-induced recovery of injuried endothelial cells, and explain the mechanism from EPCs homing. Methods The endothelial injuried rats were given gavage with BYHWD and vena caudalis injection of EPC. The repaired situation of injuried endothelium was observed. The effect of BYHWD on EPC homing was analyzed from integrin αvβ3 and integrin αvβ5-mediated SDF-1/CXCR-4 signaling pathway. Results Compared with group EPC (group E) and BYHED group (group b), the protein expression of vascular αvβ3 in BYHWD combined with EPC (group B) increased more significantly (P<0.05), vascular SDF-1 expression increased significantly (P<0.01). Conclusion BYHED could promote EPC repairing damaged endothelium, the mechanism may be related to promote EPCs homing through upregulating αvβ3-mediated SDF-1signaling pathway. |
| Key words: integrin αvβ3 integrin αvβ5 Endothelial progenitor cell Buyang Huanwu decoction homing |
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