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任晨斌,伍大华,郭晨,谢乐.滋肾活血方对血管性痴呆大鼠NR2A表达的影响[J].湖南中医药大学学报英文版,2018,38(2):141-144.[Click to copy
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| 滋肾活血方对血管性痴呆大鼠NR2A表达的影响 |
| 任晨斌,伍大华,郭晨,谢乐 |
| (湖南省中医药研究院附属医院, 湖南 长沙 410006;宁波老年康复医院, 浙江 宁波 315033) |
| 摘要: |
| 目的 探讨滋肾活血方对血管性痴呆（vascular dementia，VD）大鼠NR2A表达的影响。方法 采用改良的双侧颈总动脉结扎法（2-VO法）制作VD大鼠模型，将其随机分为假手术组、模型组、滋肾活血组及奥拉西坦组。给药4周后，用免疫组化和RT-PCR检测NR2A及其mRNA的表达。结果 与假手术组相比，模型组NR2A及其mRNA表达均降低（P<0.05）；与模型组相比，滋肾活血组及奥拉西坦组NR2A及其mRNA表达增高（P<0.05）。结论 滋肾活血方可提高VD大鼠的学习记忆能力，这可能与上调NR2A的表达有关。 |
| 关键词: 滋肾活血方 血管性痴呆 N-甲基-D-天门冬氨酸 |
| DOI：10.3969/j.issn.1674-070X.2018.02.006 |
| Received:February 19, 2017 |
| 基金项目:湖南省中医药管理局重点项目（201528）。 |
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| Effect of Zishen Huoxue Decoction on Expression of NR2A in Rats with Vascular Dementia |
| REN Chenbin,WU Dahua,GUO Chen,XIE Le |
| (The Affiliated Hostipal of Hunan Institute of Traditional Chinese Medicine, Changsha, Hunan 410006, China;Ningbo Geriatric Rehabilitation Hospital, Ningbo, Zhejiang 315033, China) |
| Abstract: |
| Objective To investigate the effect of Zishen Huoxue decoction on the expressiom of NR2A in rats with vascular dementia (VD).Methods This VD model rats were built by the improved 2-VO. The rats were randomly divide into the sham-operation group, the model group, the Zishen Huoxue group and the oxiracetam group. After giving medicine for 4 weeks later, the expression of NR2A and its mRNA were measured by immunohistochemical analysis and RT-PCR.Results Compared with the model group, the expression of NR2A and its mRNA in Zishen Huoxu decoction group and oxiracetam group increased (P<0.05).Conclusion Zishen Huoxue decoction could improve the ability of learning and memory, which might be associated with the up-regulation of the expression of NR2A. |
| Key words: Zishen Huoxue decoction vascular dementia N-methyl-D-aspartate |
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