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刘培,肖隋熙,罗颖,胡伟,简维雄,李杰.心血瘀阻证动态演变过程生物信息学研究[J].湖南中医药大学学报英文版,2018,38(2):130-135.[Click to copy
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| 心血瘀阻证动态演变过程生物信息学研究 |
| 刘培,肖隋熙,罗颖,胡伟,简维雄,李杰 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 探讨冠心病心血瘀阻证动态演变过程中血瘀证前期、亚血瘀证期、心血瘀阻证期3个阶段的代谢组学通路。方法 信号通路分析采用KEGG，代谢产物分子注释、相关的酶或转运蛋白及其相关性质分析采用HMDB，代谢产物路径可视化采用metPA网络软件。结果 用MetPA分析的生物代谢通路显示，12个代谢产物参与了22条代谢路径。其中6条通路（氨酰-tRNA生物合成、缬氨酸，亮氨酸和异亮氨酸生物合成、缬氨酸，亮氨酸和异亮氨酸生物合成及降解、精氨酸和脯氨酸代谢、半乳糖代谢，D-精氨酸与D-鸟氨酸代谢）的影响值P<0.05。结论 6条密切相关的通路主要集中在亚血瘀证期和心血瘀阻期。 |
| 关键词: 心血瘀阻证 演变过程 代谢组学 |
| DOI：10.3969/j.issn.1674-070X.2018.02.004 |
| Received:November 20, 2017 |
| 基金项目:国家自然科学基金项目（81202647，81774207，81673963）；国家重点学科项目（2014-16）；湖南省中医药科研计划项目（201427）；中国博士后基金资助（2013M530355）。 |
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| Research on Dynamic Evolution of Heart Blood Stasis Syndrome Based on Bioinformatics |
| LIU Pei,XIAO Suixi,LUO Ying,HU Wei,JIAN Weixiong,LI Jie |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To investigate the three stages of metabolic pathways on early-stage of blood stasis syndrome, sub-stage of blood stasis syndrome and stage of heart blood stasis syndrome during the dynamic evolution of heart blood stasis syndrome in patients with coronary heart disease.Methods Signal pathways were analyzed by using KEGG. Molecular annotations of metabolites, related enzymes or transporters and their associated properties were analyzed by using HMDB. Metabolic pathways visualization were analyzed by using metPA network software.Results Metabolic pathways showed that 12 metabolites were involved in 22 metabolic pathways. The influence value of 6 pathways (biosynthesis of aminoacyl-tRNA, biosynthesis of valine, leucine and isoleucine, degradation of valine, leucine and isoleucine, metabolism of arginine and proline, metabolism of galactose, metabolism of D-Arginine and D-ornithine) was P<0.05.Conclusion The six closely related pathways are mainly concentrated in sub-stage of blood stasis syndrome and stage of heart blood stasis syndrome. |
| Key words: heart blood stasis syndrome dynamic evolution metabonomics |
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