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王瑛琨,贾冬冬,刘琼,窦宇红,徐志康,刘和录.血浆miR-200c作为肺癌早期诊断的临床价值研究[J].湖南中医药大学学报英文版,2018,38(1):40-42.[Click to copy
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| 血浆miR-200c作为肺癌早期诊断的临床价值研究 |
| 王瑛琨,贾冬冬,刘琼,窦宇红,徐志康,刘和录 |
| (广州医科大学附属深圳沙井人民医院检验科, 广东 深圳 518125) |
| 摘要: |
| 目的 分析血浆miR-200c的表达与肺癌患者临床病理特征的相关性，并探讨miR-200c能否作为肺癌早期诊断的潜在肿瘤标志物的可能性。方法 收集55例肺癌患者和53例健康体检者，采用实时荧光定量PCR检测受检者血浆miR-200c的表达情况，对检测结果进行统计学分析。结果 miR-200c在肺癌患者组血浆中表达水平均高于正常对照组，差异有统计学意义（P<0.01）。受试者工作特征曲线显示miR-200c能够将肺癌与正常对照组区分出来（AUC=0.676）。结论 血浆miR-200c的表达可能与肺癌的发生有关，提示miR-200c可作为特异性生物标志物对肺癌患者进行早期诊断的可能性。 |
| 关键词: 肺癌 miR-200c 实时荧光定量PCR 早期诊断 |
| DOI：10.3969/j.issn.1674-070X.2017.01.010 |
| Received:December 14, 2016 |
| 基金项目:深圳市宝安区科技创新局社会公益项目（2014208）。 |
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| Clinical Value of Plasma miR-200c in Early Diagnosis of Lung Cancer |
| WANG Yingkun,JIA Dongdong,LIU Qiong,DOU Yuhong,XU Zhikang,LIU Helu |
| (Clinical Laboratory, Shenzhen Shajing Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518125, China) |
| Abstract: |
| Objective To analyze the correlation between plasma miR-200c expression and clinicopathological features of lung cancer patients,and to explore the possibility of miR-200c as a potential tumor marker for early diagnosis of lung cancer.Methods Fifty lung cancer patients and fifty-three healthy subjects,the expression of miR-200c in plasma was detected by real-time fluorescent quantitative PCR,and the results were statistically analyzed.Results MiR-200c expression in lung cancer patients were higher than that in normal control group and the difference was statistically significant (P<0.01).The receiver operating characteristic curve showed that miR-200c expression was able to differentiate lung cancer from the normal control group (AUC=0.676).Conclusion The expression of miR-200c in plasma may be related to the occurrence of lung cancer,suggesting that miR-200c may be a specific biomarker in patients during early diagnosis. |
| Key words: lung cancer miR-200c real time PCR early diagnosis |
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